LUMICKS presents

SMBio 2024

New York

Single molecules. Joint research.

The SMBio single-molecule biology symposium is a 2-day event, bringing together scientists interested in single-molecule approaches to biology from all over the world to share their research, connect, and exchange ideas and experiences.

Date: 17-18 October 2024
Location: Kellen Biolink at the Rockefeller University New York, NY

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Keynote speakers

Luis Aragón

MRC Laboratory of Medical Sciences
London, UK

Probing SMC Complexes and Top2 Activity on DNA: Insights from Single-Molecule Optical Tweezers

Agata Smogorzewska

The Rockefeller University
New York, USA

RTF2: Mechanisms of Function in DNA Replication and Replication Stress Response

Tim Lohman

Washington University
St. Louis, USA

Dynamics of translocases and helicases on DNA.

James Berger

Johns Hopkins School of Medicine
Baltimore, USA

Using the LUMICKS C-Trap to reassess how bacterial replicative helicases load and translocate on DNA

Speakers

Arne Gennerich

Albert Einstein College of Medicine, New York, USA

Kinesin-14 HSET and KlpA are non-processive microtubule motors with load-dependent power strokes

Micah McCauley

Northeastern University, Boston, USA

Kinetics and Energetics of Nuclear Chaperones

Yukun Wang

Rockefeller University, New York, USA

Unveiling the regulatory role of human elongation factors in RNA Polymerase II transcription with single-molecule resolution

Laura Finzi

Emory College, Atlanta, USA

Macromolecular crowders: Influencers of DNA Topology

Ayush Mistry

Saint Louis University, St. Louis, USA

Rad52 sorts and stacks Rad51 at the 5′ DNA junction to drive nucleoprotein filament formation in Homologous Recombination

Shannon Yan

Stanford University, Stanford, USA

Live cell force dynamics – Discoveries along the mechanical dimension in biology

Thomas Germe

University of Colorado, Anschutz, USA

A structural role for Topoisomerase II in resolving telomere entanglements in late anaphase

Keir Neuman

National Institute of Health, Bethesda, USA

Direct observation of type IA topoisomerase conformational dynamics

Xuebiao Yao

University of Science and Technology of China, Hefei, China

Single-molecule analyses of pioneer factor FOXA1 activity control by Aurora B

Sarah Hengel

TUFTS University, Medford, USA

The Shu complex, an exciting new RAD51 and RPA modulator

Matthew Schaich

University of Pittsburgh, USA

Nucleosome unwrapping and PARP1 conformation drive affinities for chromatin and DNA breaks

Yongli Zhang

Yale University, New Haven, USA

Energetics and kinetics of SNARE assembly revealed by optical tweezers

Vitaly Klyachko

Washington University, St. Louis, USA

Single-molecule imaging revealed nanoscale organization and metabolic plasticity of synaptic transmission

Agenda

Join us to meet world industry leaders and inspiring speakers to explore how dynamic single-molecule analysis will shape the world of tomorrow.

Day 1 – Thursday 17 October

12:00 PM	Welcome & Registration
1:00 PM	Introduction
1:20 PM	Keynote Session 1 Tim Lohmann Agata Smogorzewska
2:40 PM	Break
3:00 PM	Scientific Talk Session 1 Sarah Hengel Keir Neumann Yongli Zhang
4:15 PM	Break
4:35 PM	Scientific Talk Session 2 Xuebiao Yao Laura Finzi Thomas Germe (Poster talk) Ayush Mistry (Poster talk) Matthew Schaich
6:15 PM	Break and depart for dinner & social

Day 2 – Friday 18 October

8:00 AM	Welcome / Coffee & pastries
9:00 AM	Kickoff / Introduction Day 2
9:10 AM	Keynote Session 2 Luis Aragon James Berger
10:30AM	Poster Session & Coffee
12:30 PM	Lunch
1:30 PM	Group photo
1:50 PM	Scientific Talk Session 3 Yukun Wang Arne Gennerich Vitaly Klyachko
3:05 PM	Break
3:40 PM	Scientific Talk Session 4 Micah McCauley Shannon Yan
4:30 PM	Closing Remarks
5:00 PM	Departure