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ROS activation in macrophages optical tweezers fluorescence microscopyBlog posts

Early activation of single macrophages captured by the C-Trap®

In a recent article published in Small Methods, researchers reveal a method that uniquely captures the early phase of oxidative stress response in macrophages. Employing the powerful combination of optical tweezers, confocal fluorescent microscopy, and microfluidics of the C-Trap®, they measured the real-time intracellular response of individual macrophages to a…
j.yeh
11 March 2021
Top banner images were licensed by Jose Luis Stephens (Santiago de Chile) / Sean Pavone (Salt Lake City) / Boris Stroujko (Wurzburg) / f11photo (Tokyo) / Shutterstock.comBlog posts

LUMICKS technologies installed all around the world

As turbulent 2020 was, we are happy to have managed to install various LUMICKS instruments all around the world. Our dynamic single-molecule instruments enable researchers to analyze complex dynamic details related to the behavior and interaction of single molecules. One of these installations is the newly installed C-Trap® system at the…
j.yeh
23 February 2021
Blog posts

The softening effect of vimentin filament phosphorylation measured with the C-Trap®

A recent study published in the journal Nanoscale shows how post-translational phosphorylation and proteins binding phosphorylated sites regulate the stiffness of vimentin filaments. The researchers combined several analytical approaches and instruments, including the C-Trap® optical tweezers, to define the role of these modifications and interactions on the mechanical properties of vimentin. Apart from contributing…
j.yeh
16 February 2021
Blog posts

Evaluation of protein droplet viscoelasticity with the C-Trap® reveals new material properties

A recent publication in Science describes a new glass-like structural behavior that protein droplets can adopt, regulating their biochemical behavior as they age. Specifically, through rheological measurements using the C-Trap® optical tweezers, the researchers discovered material properties that may help cells respond to a dynamic molecular environment. The findings offer essential insights into the…
j.yeh
16 February 2021
Blog posts

Coordinated stimulation of RAD51 filament assembly and growth revealed with the C-Trap®

A recent study published in Molecular Cell used dynamic single-molecule analysis to evaluate the roles of specific proteins involved in the initiating steps of homologous recombination, including nucleation and growth of RAD51 filaments. Specifically, the researchers used the C-Trap® optical tweezers with correlated confocal microscopy to evaluate the roles of RAD51 paralogues and BRCA2…
j.yeh
16 February 2021
Blog posts

Researchers study the viscoelasticity of human cells as a response to external cues using the high-throughput AFS®

A recent publication in Small introduces you to the value of acoustic force spectroscopy (AFS®) to study the viscoelastic properties of individual cells in high throughput. The authors describe how they used this “plug-and-play” instrument to measure mechanical cell properties upon external cues seamlessly. Romanov et al. specifically assessed how alterations to…
j.yeh
16 February 2021
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