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m-Trap Optical TweezersBlog posts

Introducing m-Trap® Optical Tweezers

Today, we release the m-Trap®. Watch the launch video! The m-Trap is the first dedicated optical tweezers platform specifically designed to enable scientists to manipulate and measure at the single-molecule level with ultra-high resolution, stability & throughput, at an unprecedented price. We hope that introducing this instrument will bring us closer to the LUMICKS dream of truly unlocking single-molecule analysis.
Jerom Langeveld
23 November 2017
C-Trap installation University of ZurichBlog posts

C-Trap® installed at University of Zürich

Recently, LUMICKS successfully installed a new C-Trap® Optical Tweezers system, with a quadruple trap configuration, in the lab of Professor Ben Schuler at the University of Zürich, Switzerland. The group of Prof. Schuler uses single-molecule spectroscopy with the aim to understand protein folding, disorder and dynamics. The C-Trap® will be the group's first experience…
Jerom Langeveld
3 November 2017
Single-Molecule-Workshop-102017HQ-Lecture-by-Gijsje-KoenderinkBlog posts

Single-Molecule Workshops at LUMICKS’ headquarters

On October 23-25, LUMICKS organized two fruitful workshops on Optical Tweezers-Fluorescence Microscopy & Acoustic Force Spectroscopy at our headquarters in Amsterdam. The practical hands-on workshops included demonstrations on the latest developments and applications of the C-Trap® and  AFS™, given by our application scientists. In addition, the participants performed state-of-the-art single-molecule experiments and…
Jerom Langeveld
31 October 2017
correlative-optical-tweezers-fluorescence-workshopBlog posts

Optical Tweezers-Fluorescence Microscopy Workshops at the Rockefeller University

On October 10-12, the lab of Prof. Shixin Liu at the Rockefeller University in New York hosted two successful workshops on Optical Tweezers-Fluorescence Microscopy, organized by LUMICKS. During the practical hands-on workshops, the participants learned about the latest developments and applications of the C-Trap®. Furthermore, together with our application scientists, they conducted…
Jerom Langeveld
20 October 2017
DNA BreathingBlog posts

DNA Breathing Application Note Now Online

DNA breathing, also known as fraying, describes the spontaneous local conformational transitions occurring within double-stranded DNA (dsDNA). Due to the transient and spontaneous nature of this process, the study of real-time DNA breathing transitions at the single-molecule level requires the use of highly sensitive experimentation technologies. Using LUMICKS’ high-resolution optical tweezers, small and transient DNA…
Jerom Langeveld
28 September 2017
strand-displacement polymerization investigated with u-Flux microfluidics microfluidics laminar flow cellBlog posts

Strand-Displacement Polymerization by Reverse Transcriptase Investigated using LUMICKS’ u-Flux™

The journal Nucleic Acids Research has recently published the paper "Pausing kinetics dominates strand-displacement polymerization by reverse transcriptase". We would like to congratulate the authors! Malik et al. (2017) used optical tweezers and, among other technologies, microfluidics to study the enzymatic activity of the murine leukemia Virus reverse transcriptase (RT). RT catalyzes the formation of an integration-competent double-stranded DNA…
Jerom Langeveld
26 September 2017
BIOCEV customer case story - Academy of Sciences of the Czech Republic, Faculty of Science and the First Faculty of Medicine of the Charles University in PragueBlog posts

Customer Case Story BIOCEV Prague

In January 2016, LUMICKS’ first C-Trap® Optical Tweezers-Fluorescence Microscopy instrument was successfully installed at the BIOCEV research center in the Czech Republic. BIOCEV is a research institute in the areas of biotechnology and biomedicine of both the Academy of Sciences of the Czech Republic and the Charles University. The instrument…
Jerom Langeveld
13 September 2017
cytoskeleton filament manipulation using optical tweezers fluorescence microscopyBlog posts

Filament Manipulation Application Note Now Online

Protein filaments have been studied indirectly using various approaches of fluorescence microscopy in cells and tissues and more directly, using force spectroscopy on single filaments or filament bundles. LUMICKS' C-Trap® provides for a unique approach which combines the strength of both techniques, to give a truly correlative method of studying…
Jerom Langeveld
6 September 2017
C-Trap Chemical Reviews AFS Biochemical Society TransactionsBlog posts

C-Trap® and AFS™ systems mentioned in two review articles

We are proud to announce that two review articles refer to LUMICKS; one highlighting the C-Trap® Optical Tweezers-Fluorescence Microscopy system and the other one specifying the AFS™ Acoustic Force Spectroscopy system.  Norregaard et al. (2017) reviews relevant theoretical tools to analyze data obtained from single-molecule experiments performed in intracellular environments and describes state-of-the art visualization techniques…
Jerom Langeveld
6 July 2017
Acoustic force spectroscopy Pasteur Institute Paris Thierry RoseBlog posts

AFS™ Installed at Pasteur Institute in Paris

The first  AFS™ system in France has been successfully installed at the lab of Dr. Thierry Rose at the Pasteur Institute in Paris. Dr. Rose and his team use AFS to manipulate human lymphocytes in living conditions to gain insights in the early steps of cytokine-induced signaling and how this…
Jerom Langeveld
16 June 2017
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