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Blog posts

A new DNA–protein coupling procedure improves stability for DSM analyses

A recent study in Communications Chemistry shows how a research lab at AMOLF in the Netherlands optimized DNA–protein coupling to study dynamic processes requiring high forces and long-term assessments. Using their C-Trap® Optical Tweezers – Fluorescence Microscopy system, the team showed the superiority of a ligation-based strategy to create long…
j.yeh
5 March 2020
Blog posts

Study shows how chaperone enzyme ClpB processively translocates polypeptide loops using C-Trap® correlated optical tweezers and confocal microscopy

A new study published in Nature reports how researchers verified the intricate process of disaggregating entangled proteins by analyzing chaperone enzyme ClpB at a single-molecule level. The C-Trap® correlated optical tweezers and confocal microscopy enabled them to analyze how the member of the Hsp100 chaperone family translocates looped polypeptide substrates…
j.yeh
13 February 2020
Top banner image was licensed by Sergey Novikov / Shutterstock.comBlog posts

C-Trap® installed at Technical University of Munich

We are happy to announce the recent installation of the C-Trap® at the Technical University of Munich, Germany, in the lab of Prof. Matthias Rief. The installed C-Trap combines optical tweezers with 2-color fluorescence microscopy and will be used by students and postdocs in the Rief lab. Among other areas,…
j.yeh
11 February 2020
Blog posts

Dynamic Single-Molecule Workshops in North and South of China

Last week we organized two dynamic single-molecule workshops in the North and South of China – one at Tsinghua University in Beijing, and another at  Sun Yat-sen University (SYSU). Both workshops included in-depth lectures exploring different state-of-the-art single-molecule applications and hands-on demonstrations of the C-Trap® Optical Tweezers – Fluorescence & Label-free Microscopy technologies. With…
j.yeh
18 December 2019
Blog posts

C-Trap® installed at Tel Aviv University

  We are happy to announce the recent installation of the C-Trap™ at Tel Aviv University, Israel, in the lab of Dr. Raya Sorkin. The C-Trap combines optical tweezers with confocal microscopy and is now available to students and postdocs in Dr. Sorkin’s lab, as well as several collaborators on…
j.yeh
11 December 2019
Blog posts

Single-molecule study assesses how cohesin complexes bridge DNA molecules using C-Trap® correlated optical tweezers with fluorescence microscopy

In a new study published in the journal Science Advances, Gutierreu-Flux™Escribano et al. studied the role of cohesin complexes in DNA tethering to gain a better understanding of sister chromatid cohesion. Using the C-Trap correlated optical tweezers with fluorescence microscopy, they observed in real-time intermolecular (DNA–DNA) and intramolecular cohesin-derived DNA bridge…
j.yeh
5 December 2019
Top banner image was licensed by The University of Vermont / Flickr.Blog posts

C-Trap® installed at University of Vermont

We are happy to announce the recent installation of the C-Trap® at the University of Vermont Larner College of Medicine. Several labs will use the correlated optical tweezers – fluorescence microscopy instrument to investigate the dynamics of molecular machines that interact with their tracks to generate force and motion. These processes are…
j.yeh
22 October 2019
C-Trap Albert Einstein College of MedicineBlog posts

C-Trap® installed at Albert Einstein College of Medicine

We are happy to announce the installation of the C-Trap™ at the Albert Einstein College of Medicine in New York in the lab of Prof. Dr. Arne Gennerich. The instrument combines optical tweezers with 3-color total internal reflection fluorescence (TIRF; a technology that reduces fluorescence background noise in surface-based assays)…
j.yeh
1 October 2019
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