News – Page 13

Blog posts

Study shows how chaperone enzyme ClpB processively translocates polypeptide loops using C-Trap^® correlated optical tweezers and confocal microscopy

A new study published in Nature reports how researchers verified the intricate process of disaggregating entangled proteins by analyzing chaperone enzyme ClpB at a single-molecule level. The C-Trap® correlated optical tweezers and confocal microscopy enabled them to analyze how the member of the Hsp100 chaperone family translocates looped polypeptide substrates…

j.yeh13 February 2020

Top banner image was licensed by Sergey Novikov / Shutterstock.com

Blog posts

C-Trap^® installed at Technical University of Munich

We are happy to announce the recent installation of the C-Trap® at the Technical University of Munich, Germany, in the lab of Prof. Matthias Rief. The installed C-Trap combines optical tweezers with 2-color fluorescence microscopy and will be used by students and postdocs in the Rief lab. Among other areas,…

j.yeh11 February 2020

Blog posts

Dynamic Single-Molecule Workshops in North and South of China

Last week we organized two dynamic single-molecule workshops in the North and South of China – one at Tsinghua University in Beijing, and another at Sun Yat-sen University (SYSU). Both workshops included in-depth lectures exploring different state-of-the-art single-molecule applications and hands-on demonstrations of the C-Trap® Optical Tweezers – Fluorescence & Label-free Microscopy technologies. With…

j.yeh18 December 2019

Blog posts

C-Trap^® installed at Tel Aviv University

We are happy to announce the recent installation of the C-Trap™ at Tel Aviv University, Israel, in the lab of Dr. Raya Sorkin. The C-Trap combines optical tweezers with confocal microscopy and is now available to students and postdocs in Dr. Sorkin’s lab, as well as several collaborators on…

j.yeh11 December 2019

Blog posts

Single-molecule study assesses how cohesin complexes bridge DNA molecules using C-Trap^® correlated optical tweezers with fluorescence microscopy

In a new study published in the journal Science Advances, Gutierreu-Flux™Escribano et al. studied the role of cohesin complexes in DNA tethering to gain a better understanding of sister chromatid cohesion. Using the C-Trap correlated optical tweezers with fluorescence microscopy, they observed in real-time intermolecular (DNA–DNA) and intramolecular cohesin-derived DNA bridge…

j.yeh5 December 2019

Blog posts

New application note shows how to study processes associated with phase separation in real time using the C-Trap^®

We are excited to tell you that our application note Manipulate and Study Protein Droplet Dynamics and Properties in Real Time to Understand Phase Separation is now available to download. Here, you can learn how to unravel the properties, formation, and nature of protein droplets, associated with both healthy and…

j.yeh28 November 2019

Blog posts

Study finds essential Cas9–DNA interaction downstream of PAM using a single-molecule approach

A new publication shows how the lab of Dr. Bo Sun used the m-Trap® to analyze the interactions between a Cas9–gRNA complex and DNA. Using a single-molecule approach to unzip the target double-stranded DNA, the team showed interaction points on the DNA that affected Cas9 binding and cleavage. These results can…

j.yeh21 November 2019

Top banner image was licensed by The University of Vermont / Flickr.

Blog posts

C-Trap^® installed at University of Vermont

We are happy to announce the recent installation of the C-Trap® at the University of Vermont Larner College of Medicine. Several labs will use the correlated optical tweezers – fluorescence microscopy instrument to investigate the dynamics of molecular machines that interact with their tracks to generate force and motion. These processes are…

j.yeh22 October 2019

C-Trap Albert Einstein College of Medicine

Blog posts

C-Trap^® installed at Albert Einstein College of Medicine

We are happy to announce the installation of the C-Trap™ at the Albert Einstein College of Medicine in New York in the lab of Prof. Dr. Arne Gennerich. The instrument combines optical tweezers with 3-color total internal reflection fluorescence (TIRF; a technology that reduces fluorescence background noise in surface-based assays)…

j.yeh1 October 2019

Blog posts

New application note shows how to study Cas9 target specificity at the single-molecule level using the C-Trap^®

We are happy to announce that our application note Analyze Cas9 Binding and Cleavage Properties in Real Time while Manipulating DNA Structures is available to download on our website. In this application note, you can learn how the group of Prof. Dr. David Rueda used the C-Trap™ optical tweezers –…

j.yeh26 September 2019

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