Lakeview
Next level Dynamic Single-Molecule data analysis
Acquire statistical insights across multiple measurements at the single-molecule level in only a few clicks.
Part of:
Explore and export all your experimental data through an easy to use and responsive interface
Discover insights quickly and focus on the science through no-code data analysis and automatically calculated output parameters
Reveal the most relevant protein information including binding kinetics, diffusion characteristics, dynamics, colocalization and enzymatic mechanisms
A new way to analyze
Dynamic single-molecule research has long been recognized for its value in providing clear insights into the molecular mechanisms of biology. However, for a very long time, this realm of science has only been accessible to experts.By providing an ecosystem of tools, LUMICKS is making this science available to everyone. Lakeview revolutionizes how dynamic single-molecule data analysis is done and is essential in answering key questions in molecular biology to characterize DNA-binding proteins, including binding kinetics, diffusion characteristics, dynamics, colocalization, and enzymatic mechanisms.
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An in-depth guide to our newest features
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Download the latest release of Lakeview below. After installation you can view and organize your Dynamic Single-Molecule data right away.
Technical note:
Filter DSM and show 4 latest
This shows the most recent card of each resource type filtered on Business Unit
Webinar, Scientific update, Whitepaper, Application note, Brochure.
We only show 4 and we have 6 types so the 2 older ones are hidden.
In design only 1 is shown, but the rest will be loaded when published.
Filter DSM and show 4 latest
This shows the most recent card of each resource type filtered on Business Unit
Webinar, Scientific update, Whitepaper, Application note, Brochure.
We only show 4 and we have 6 types so the 2 older ones are hidden.
In design only 1 is shown, but the rest will be loaded when published.
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Mechanisms of chromatin remodeler target search and nucleosome mobilization
Webinar
September 12, 2025
01-01-20
Chromatin remodelers play a pivotal role in gene regulation by shaping the physical structure of DNA around promoters and regulatory elements. While their biochemical activities are well studied, existing analytical methods fall short in capturing their dynamic activity and the mechanisms by which they search for and engage their targets. This limitation hinders deeper functional assessment, which is essential to the drug development process.
This webcast will explore how individual remodeler proteins including SWR1, RSC, and ISW2 navigate the chromatin landscape by scanning, sliding or hopping to locate and reposition nucleosomes, ultimately influencing access to DNA by transcription machinery. It will feature recent discoveries using single- and dual-color single-molecule tracking with optical tweezers to investigate the one-dimensional (1D) diffusion behaviors of three conserved yeast remodelers—SWR1, RSC, and ISW2—on DNA and sparse nucleosome arrays.
The findings reveal a unified framework for how chromatin remodelers navigate chromatin landscapes to regulate promoter accessibility through coordinated search and remodeling dynamics. They offer new insights into the physical mechanisms underlying gene expression and genome organization, while opening avenues for further exploration of chromatin dynamics and therapeutic strategies.
Text Link
Linking Mechanical Stability with in vivo Recombination: Single-molecule Research Reveals Bacterial Antibiotic Resistance
Scientific update
January 4, 2025
01-01-20
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Golden Gate meets C-Trap: A powerful combination for unprecedented molecular insights
Application note
December 18, 2024
01-01-20
Precisely manipulating genetic material at the single molecule level is gaining importance across life sciences – and so do the tools that allow researchers to do exactly that. The C-Trap system combines single molecule fluorescence microscopy with optical tweezers to manipulate DNA, allowing researchers to directly observe and track molecular events as they occur. Designing and creating specific DNA constructs is crucial for maximizing the potential of single molecule studies. In this application note we introduce the powerful combination of cutting edge biochemistry and single-molecule visualization methods to increase throughput and maximize the results gained from each individual measurement.
C-Trap Product Brochure
Brochure
February 28, 2025
01-01-20
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