Lakeview
Next level Dynamic Single-Molecule data analysis
Acquire statistical insights across multiple measurements at the single-molecule level in only a few clicks.
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Explore and export all your experimental data through an easy to use and responsive interface
Discover insights quickly and focus on the science through no-code data analysis and automatically calculated output parameters
Reveal the most relevant protein information including binding kinetics, diffusion characteristics, dynamics, colocalization and enzymatic mechanisms
A new way to analyze
Dynamic single-molecule research has long been recognized for its value in providing clear insights into the molecular mechanisms of biology. However, for a very long time, this realm of science has only been accessible to experts.By providing an ecosystem of tools, LUMICKS is making this science available to everyone. Lakeview revolutionizes how dynamic single-molecule data analysis is done and is essential in answering key questions in molecular biology to characterize DNA-binding proteins, including binding kinetics, diffusion characteristics, dynamics, colocalization, and enzymatic mechanisms.
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Download the latest release of Lakeview below. After installation you can view and organize your Dynamic Single-Molecule data right away.
Technical note:
Filter DSM and show 4 latest
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Webinar, Scientific update, Whitepaper, Application note, Brochure.
We only show 4 and we have 6 types so the 2 older ones are hidden.
In design only 1 is shown, but the rest will be loaded when published.
Filter DSM and show 4 latest
This shows the most recent card of each resource type filtered on Business Unit
Webinar, Scientific update, Whitepaper, Application note, Brochure.
We only show 4 and we have 6 types so the 2 older ones are hidden.
In design only 1 is shown, but the rest will be loaded when published.
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New Insights in Chromosome Organization: Single Molecule Analysis of Eukaryotic SMC Complexes
Webinar
March 31, 2025
01-01-20
Structural Maintenance of Chromosome (SMC) complexes, cohesin, condensin and Smc5/6, play a fundamental role in genome organization, facilitating chromosome compaction, segregation, and DNA repair. Despite their essential functions, the mechanisms by which the complexes interact with different DNA substrates and influence topological transitions remain not fully understood. Using the LUMICKS C-Trap, we have employed single-molecule approaches to analyze the behavior of purified SMC complexes, focusing on yeast cohesin and human SMC5/6, on different DNA substrates, including double-stranded (dsDNA) and single-stranded DNA (ssDNA). Additionally, we have used a quadrupole optical trap to bridging by SMC complexes and their effect on DNA decatenation by Topoisomerase IIα (Top2A). These findings provide new insights into the fundamental properties and requirements of cohesin and Smc5/6’s interaction with DNA substrates, as well as their ability to bridge two independent DNAs.
Text Link
Deciphering the Dynamic Mechanisms of Thymine DNA Glycosylase (TDG) in DNA Repair
Scientific update
December 5, 2024
01-01-20
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Golden Gate meets C-Trap: A powerful combination for unprecedented molecular insights
Application note
December 18, 2024
01-01-20
Precisely manipulating genetic material at the single molecule level is gaining importance across life sciences – and so do the tools that allow researchers to do exactly that. The C-Trap system combines single molecule fluorescence microscopy with optical tweezers to manipulate DNA, allowing researchers to directly observe and track molecular events as they occur. Designing and creating specific DNA constructs is crucial for maximizing the potential of single molecule studies. In this application note we introduce the powerful combination of cutting edge biochemistry and single-molecule visualization methods to increase throughput and maximize the results gained from each individual measurement.
C-Trap Product Brochure
Brochure
February 28, 2025
01-01-20
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All products and technologies are for Research Use Only (RUO) except when specifically noted