Webinars

Part of: Knowledge repository

Monthly webinar series

Immuno-oncology digests

In this online seminar series, we review the biological principles behind immunotherapy and how measurements of cell avidity may be used as a functional biomarker to help fundamentally improve cell therapy development.

Immuno-oncology digests #7: Considerations for optimal CAR design

NEW While chimeric antigen receptor (CAR)-T cells have had shown great potential in the past decade, their success has been limitedTo date, only 5 therapies have been FDA approved, all of them targeting either of two antigens for the treatment of liquid tumors while no success has been achieved in treating solid cancers. Additionally, of the patients that are treated, only about half show good response, while the rest either relapse of do not show response at all. To combat those issues, CAR researchers have focused on different strategies to enhance the success of CAR T therapy, starting with revisiting the design of the CAR constructs. In pre-clinical models, the construct design has been shown to greatly influence T-cell efficacy and persistence, both of which are critical for the success of CAR T therapy.

In this webinar focused on CAR-T cells, we will:

  • Review the evolution of CAR design
  • Present recent data supporting how cell avidity, a new and crucial biomarker in immuno-oncology, is providing new insights into CAR-T cell function in vitro as well as in vivo preclinical outcomes.
  • Discuss how cell avidity can allow better characterization of CAR-T cells and provide insights into optimizing binding avidity for downstream applications, including clinical candidate selection.

Time and Date
September 7, 2022 04:00 PM CET/ 09:00 AM CT/ 10:00 AM ET
September 8, 2022 10:00 AM CET/ 04:00 PM CST

Speaker
Dr. Jens Eberlein, Technical Lead, Immuno-Oncology from LUMICKS

Register here

Immuno-oncology digests #6: Tight regulation of co-stimulatory signals and how that determines CD8+ T cell polyfunctionality

In this webinar, Dr. Reza Nadafi, Cell Therapy T Cell Biology Lead from LUMICKS, talked about how CD8+ T cell function is tightly controlled by a combination of co-stimulatory signals. Using the latest cell avidity data, he showed how measuring cell avidity helps researchers to understand which co-stimulatory molecules are critical for polyfunctional cytokine production in CD8+ T cells, and improve T cell function.

Are you interested to learn about different immuno-oncology related topics?

Watch all past IO digests here!

Keynote speaker webinars

Seminars from world-leading experts

Don’t miss world-renowned researchers talk about their experience with cell avidity measurements for T cell functionality prediction.

Application webinars

Deep-dive into the applications with LUMICKS’ scientists

Watch our webinars presented by expert speakers, covering the latest breakthroughs and developments in immuno-oncology.

Cellular avidity: a missing link for efficacious immunotherapy

Explore experiments across the topics of CAR-T cells, TCR T cells, NK cells, and bispecific antibody-engaged T cells, showing a correlation between avidity and T cell functionality.

Rapid identification of Goldilocks CAR T cells using z-Movi Cell Avidity Analyzer

Discover how measuring cellular avidity using the z-Movi Cell Avidity Analyzer helps researchers to quickly identify optimal functioning CARs and compare between panels.

Fast and accurate prediction of optimal TCR function using z-Movi Cell Avidity Analyzer

How does the z-Movi Cell Avidity Analyzer measure cell avidity? Why does avidity matter in TCR-dependent T-cell cytotoxicity? How does it compare with functional assays?

Unveiling a one-to-one relationship of TCR-dependent T cell function and cellular avidity

We present avidity data, obtained by Dr. Nathalie Rufer’s research team at the University of Lausanne, showing a linear correlation between T cell function and cell avidity.

Watch past webinars

Download the video recording and slide deck of past webinars

Watch our webinars presented by expert speakers, covering the latest breakthroughs and developments in immuno-oncology.

Fill in the form below to watch previously-held webinars on-demand. If you miss something don’t hesitate to let us know!


The above videos are also available in Chinese, please visit https://lumicks.com/knowledge/ca-webinars-china/ to access Chinese videos.

Join our mailing list.

Get exclusive news on the latest products, single-molecule events and breakthrough science.

By agreeing to receive marketing communications, you subscribe to our newsletter. You can change your mind at any time by clicking the unsubscribe link in any marketing email you receive from us. By submitting the form you agree to LUMICKS' privacy policy.

Join our newsletter

Join our newsletter

Get exclusive news on the latest publications, product developments, events and breakthrough science.

By agreeing to receive marketing communications, you subscribe to our newsletter. You can change your mind at any time by clicking the unsubscribe link in any marketing email you receive from us. By submitting the form you agree to LUMICKS' privacy policy.

Download our webinar recording:

 

Download our Cell Therapy (CAR-T, TCR, NK) applications deck