不要错过世界知名的研究人员的报告！与他们探讨使用细胞复合亲合力测量预测 T 细胞功能的经验。
Cell Avidity Measurements to Understand and Enhance CAR-T/Tumor InteractionsWatch this webinar to learn about novel CARs and the use of avidity measurements to understand and enhance productive CAR-T cell interactions with both liquid and solid tumors from Dr. Marcela Maus, Director of cellular immunotherapy at Harvard Medical school.
Cell avidity as a crucial biomarker for CAR T response
Dr. Rebecca Larson presented her work on “Loss of IFNγR signaling and downstream adhesion confers resistance to CAR T cell cytotoxicity in solid but not liquid tumors” in Nature. Learn how cell avidity measurements can improve CAR T cell response in solid tumors by identifying important evasion mechanism.
CAR T-Cell Immunotherapy of Solid Tumors – Learning from the Clinic and Lab in Parallel
Learn about Leucid Bio’s efforts in developing a next-generation CAR platform, known as parallel (p)CAR. In this webinar, Dr. John Maher demonstrated how to use the z-Movi to address the importance of relative binding affinity in the design of optimized pCAR?
Combining a CAR and a chimeric costimulatory receptor enhances T-cell sensitivity to low antigen density and promotes persistence
Learn from Dr. Maria Themeli how to overcome low antigen density and improve CAR-T cell persistence with multi-targeting and co-stimulation through increasing synaptic avidity with the z-Movi.
Exploring the network of cellular interactions of NK cells in the tumor microenvironment
Learn from Prof. Lowdell how primed NK cells become effective against resistant tumor cells, and how cell avidity measurements were used to depict a stronger binding of primed NK cells, resulting in improved tumor cell killing.
Dual-targeted cell therapy targeting BCMA and GPRCD5 to prevent relapse in multiple myeloma
Learn from Prof. de Larrea how expressing two CARs on a single cell enhances the strength of CAR T-cell/target cell interactions, prevents BCMA escape-driven relapse, and how cell avidity measurements contributed to their findings.
Cellular avidity: a missing link for efficacious immunotherapy
Explore experiments across the topics of CAR-T cells, TCR T cells, NK cells, and bispecific antibody-engaged T cells, showing a correlation between avidity and T cell functionality.
Rapid identification of Goldilocks CAR T cells using z-Movi Cell Avidity Analyzer
Discover how measuring cellular avidity using the z-Movi Cell Avidity Analyzer helps researchers to quickly identify optimal functioning CARs and compare between panels.
Fast and accurate prediction of optimal TCR function using z-Movi Cell Avidity Analyzer
How does the z-Movi Cell Avidity Analyzer measure cell avidity? Why does avidity matter in TCR-dependent T-cell cytotoxicity? How does it compare with functional assays?
Unveiling a one-to-one relationship of TCR-dependent T cell function and cellular avidity
We present avidity data, obtained by Dr. Nathalie Rufer’s research team at the University of Lausanne, showing a linear correlation between T cell function and cell avidity.