Learn dynamic single-molecule

Get a better understanding of dynamic single-molecule analysis, why is it important and relevant, and the working principle of our technology to measure and visualize biomolecular processes as they happen.

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Professor David Rueda, Imperial College London and MRC – Laboratory of Medical Sciences

FANCD2-FANCI surveys DNA and recognizes double- to single-stranded junctions

Professor Nynke Dekker, Technical University Delft, Netherlands

Studying DNA and chromatin replication using integrated force-fluorescence microscopy

Bennett van Houten, PhD Professor of Molecular Oncology UPMC Hillman Cancer Center University of Pittsburgh, USA

Single-molecule analysis of cancer DNA-protein interactions from nuclear extracts

Professor Guillermo Montoya, University of Copenhagen, Denmark

Unlocking the Power of Cas12a: Novel Insights into Engineered Endonucleases for Safe and Precise next generation Genome Editing

Professor Fernando Moreno-Herrero, National Center for Biotechnology Madrid, Spain

Insights into Bacterial DNA Condensation and chromosome organization

Professor Arne Gennerich, Albert Einstein College of Medicine, New York, USA

Single-molecule analysis of variants of the cytoskeletal motor protein KIF1A and their impact on neuronal transport processes and development: A C-Trap Edge study

Professor Ingrid Tessmer, University of Würzburg, Germany

A Deep Dive into Nucleotide Excision Repair (NER) and its Crucial Role in Alkyl-DNA Lesion Repair and Cancer Prevention

Professor Priya R. Banerjee, University of Buffalo, USA

Decoding the onset of Amyotrophic Lateral Sclerosis (ALS): Liquid-liquid phase transition of Intrinsically Disordered Proteins

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Dynamic single-molecule analysis offers invaluable insights into DNA repair mechanisms: HELQ in DSB case study

Dr. Simon Boulton Principal Group Leader at The Francis Crick Institute

Manipulate and study protein droplet dynamic and properties in realtime to understand phase separation

Dr. Priya Banerjee Associate Professor of Biophysics at University at Buffalo

Optical tweezers combined with STED reveals protein dynamics on densely covered DNA

Prof. Dr. Gijs Wuite and Prof. Dr. Erwin Peterman at the Vrije Universiteit Amsterdam

Single-molecule visualisation of DNA repair mechanisms and non-homologous end joining (NHEJ)

Prof. Dr. Gijs Wuite and Prof. Dr. Erwin Peterman at the Vrije Universiteit Amsterdam

Learn about our technology

Correlated optical tweezers with fluorescence microscopy

The combination of optical tweezers and fluorescence microscopy allows for simultaneous manipulation and visualization of molecular interactions in real-time.

What are optical tweezers?

Arthur Ashkin won the Nobel Prize in Physics “for the optical tweezers and their application to biological systems”. In essence, he discovered that light’s momentum could serve as an incredibly sensitive set of tweezers to catch and study biomolecules

IRM (label-free)

IRM allows you to visualize microtubules without the need for fluorescence labeling

TIRF

Suitable for visualization on surfaces as it eliminates background fluorescence outside the focal plane

STED Super Resolution

STED nanoscopy allows you to distinguish between individual DNA-binding proteins in close proximity

Confocal

The confocal microscope emits light by a laser through a pinhole that allows a specific light wavelength to pass

Widefield

Widefield fluorescence microscopy illuminates the sample from below and uses light of frequencies that can excite fluorescent molecules associated to your sample

Latest scientific updates

Revealing MeCP2 Mechanism: Single-Molecule Insights into Epigenetic Regulation in Neurodevelopmental Disorders

Methyl-CpG-binding protein 2 (MeCP2) is a key regulator of gene expression, primarily known for its role in binding to methylated DNA at CpG sites to suppress gene activity…

DNA Polymerase Undergoes Rapid Exchange and Retains Memory at Replication Forks

For decades, researchers have been on a quest to unravel the elusive mechanisms governing DNA polymerase exchange during replication—a process essential for genomic integrity and genome replication. Despite the central role…

Key mechanism in Fanconi Anemia pathway discovered with the C-Trap

The maintenance of genomic stability is crucial for the prevention of cancer and other diseases. One of the key players in this process is the Fanconi anemia (FA) pathway…

Chromatin remodeling dynamics revealed at the single-molecule level in a recent pioneering study

Chromatin structure and remodeling is a fundamental process that ensures the dynamic regulation of DNA accessibility in our cells. This process is crucial for essential functions such as…

Securing Broken DNA Ends: PARP1’s Vital Role in Co-Condensation with DNA

DNA double-strand breaks (DSBs) are critical lesions that, if not properly repaired, can result in chromosomal rearrangements and genomic instability…

Unveiling Key Mechanisms in Kinetochore-Mediated Chromosome Segregation with the C-Trap

Errors in chromosome segregation can lead to profound genetic abnormalities, paving the way…

Towards safe and precise gene therapies: revealing the impact of DNA Supercoiling on CRISPR-Cas9 specificity

CRISPR-Cas9 represents one of the most impactful discoveries in the field of genetic engineering and medicine of recent times…

The C-Trap uncovers new insights into the mechanisms for ATP-dependent chromatin remodeling

PICH (Plk1-interacting checkpoint helicase) belongs to the SNF2 family of ATP-dependent chromatin remodelers…

Cell mechanics with the C-Trap – cellular tension propagation revisited

Surprising insights into the roles of membranes and the actin cytoskeleton in cellular tension propagation – congratulations to all authors for successfully implementing a new and elegant assay with the C-Trap…

C-Trap^® experiments shed light on the mechanisms that govern Structural Maintenance of Chromosome (SMC) Complexes

In two recent scientific publications, Johannes Stigler and his team from the Gene Center of the…

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