The C-Trap® is a dynamic single-molecule microscope that allows to visualize the dynamics of individual proteins. Its unique Nobel Prize winning technology allows – within the same experiment – to:
- Obtain direct evidence of how the molecular mechanisms and dynamic processes of proteins on DNA work.
- Observe the stepwise assembly of the biological complex.
- Modulate the molecular system to test the model under different conditions.
This dynamic single-molecule technology is rapidly evolving as a mainstream approach in research for the study of DNA-binding proteins, molecular motor activity, protein folding, and protein droplets. Our systems are currently in use by core facilities molecular and structural biologists, biochemists, and biophysicists across the globe, including Stanford, JHU, Tsinghua University, and NIH. If you would like to get some inspiration from this technology, check out the following recent papers:
- Wasserman, M. et al.Replication Fork Activation Is Enabled by a Single-Stranded DNA Gate in CMG Helicase.Cell 2019, 178(3): 600-611.e616.
- Khawaja, A. et al. Distinct pre-initiation steps in human mitochondrial translation. Nature Communications 2020, 11(1): 2932.