Blog posts Archives - Page 2 of 19

Blog posts

m-Trap^® allows precise control of biological activities in synthetic membraneless organelles (MLOs) in real time

Until recently, the understanding of membraneless organelles (MLOs) was hindered by the inability to control their bioactivities in a precise manner. In a recent Nature Communications article from the lab of Huang and Sun, University of Hong Kong, researchers were able to overcome this obstacle by producing synthetic MLOs that…

j.yeh23 August 2022

Blog posts

LUMICKS’ C-Trap^® adopted by two labs at UBC

We are delighted to announce the installation of two C-Trap® instruments at the University of British Columbia (UBC), Vancouver, Canada, in the labs of Dr. Derek Dee and Dr. Nada Lallous. Derek Dee, Assistant Professor in the Department of Land and Food Systems, focuses his research on the forces that…

Rozina Kardakaris14 July 2022

Blog posts

Dynamic single-molecule analysis reveals non-linear stiffening of mitotic chromosomes

In a recent study performed by Vrije Universiteit Amsterdam and the University of Copenhagen, researchers used LUMICKS’ u-Flux™ laminar flow microfluidics system together with optical tweezers and fluorescence microscopy – features combined in LUMICKS’ C-Trap® – to shed light on the structural organization of mitotic chromosomes. When preparing to undergo…

Rozina Kardakaris17 June 2022

Blog posts

C-Trap^® studies reveal GroEL-ES protein folding acceleration mechanism

In a recent Science Advances publication, the group of Sander J. Tans from the AMOLF Institute, The Netherlands, demonstrate for the first time, at the single molecule level, how the molecular chaperone GroEL-ES modulates protein chain collapse and stimulates protein folding. Using LUMICKS’ C-Trap®, they were able to follow and visualize…

Rozina Kardakaris17 May 2022

Blog posts

New C-Trap^® installation at Radboud University to offer insights into chromatin organization

We are thrilled to announce the installation of a C-Trap® at the RIMLS-Science institute, Radboud University, The Netherlands, in the lab of Dr. Jorine Eeftens. The installed C-Trap combines dual-trap optical tweezers with super-resolution confocal microscopy, which will allow the team to perform and visualize single-molecule experiments with unprecedented detail to…

Rozina Kardakaris14 April 2022

Blog posts

Exploring biomolecular condensate dynamics with the C-Trap^® reveals viscoelastic fluid behavior

In a recent article published in Nature Communications by the group of Huan-Xiang Zhou from the University of Illinois, Dr. Archishman Ghosh and co-workers provided insights into the dynamics of biomolecular condensates. Using LUMICKS’ C-Trap® with a dual-trap optical tweezer configuration they obtained direct evidence showing that phase-separated biopolymer condensates…

Rozina Kardakaris31 March 2022

C-Trap reveals mechanism of protein-DNA co-condensate formation.

Blog posts

C-Trap^® experiments reveal mechanism of protein-DNA co-condensate formation

In a recent publication in PNAS, researchers from the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) and the Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) shed light on how proteins interact with individual DNA molecules to form co-condensates. Using LUMICKS’ C-Trap®, which combines optical tweezers, confocal microscopy, and…

Rozina Kardakaris16 March 2022

Blog posts

C-Trap^® experiments reveal how a pioneer transcription factor interacts with DNA to regulate gene expression

Researchers from the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, Germany, led by Stephan W. Grill, have shed light on the physical nature of the interaction between the pioneer transcription factor Klf4 (Krüppel-like factor 4) and DNA. Using the C-Trap®, which combines optical tweezers, confocal microscopy…

Rozina Kardakaris23 February 2022

iScience_monocyte mechanics_Alireza-Mashaghi_optical tweezers_acoustic force spectroscopy

Blog posts

Probing monocyte forces with the C-Trap^® and acoustic force spectroscopy reveals CCL2 regulation of monocyte mechanics

In a first-of-its-kind study from Leiden University, Evers et al. have provided insights into the mechanical properties of monocytes – cells crucial in the fight against infection. By combining two of LUMICKS’ single-cell force spectroscopy approaches, C-Trap® optical tweezers and acoustic force spectroscopy (AFS), they were able to determine that…

Rozina Kardakaris16 February 2022

Lyon, France by Pedro Szekely / flickr.com

Blog posts

LUMICKS’ C-Trap^® adopted by 8 teams in 3 multidisciplinary labs in France

We are thrilled to announce the recent C-Trap® installation at École Normale Supérieure Lyon, now the first establishment in France to acquire a C-Trap, where it will be utilized by an astonishing 8 teams across 3 departments! The Physics Department (LPENSL), Cell Biology Department (LBMC), and Plant Biology Department (RDP)…

Adrià Ferragut28 January 2022

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Blog posts

m-Trap^® allows precise control of biological activities in synthetic membraneless organelles (MLOs) in real time

LUMICKS’ C-Trap^® adopted by two labs at UBC

Dynamic single-molecule analysis reveals non-linear stiffening of mitotic chromosomes

C-Trap^® studies reveal GroEL-ES protein folding acceleration mechanism

New C-Trap^® installation at Radboud University to offer insights into chromatin organization

Exploring biomolecular condensate dynamics with the C-Trap^® reveals viscoelastic fluid behavior

C-Trap^® experiments reveal mechanism of protein-DNA co-condensate formation

C-Trap^® experiments reveal how a pioneer transcription factor interacts with DNA to regulate gene expression

Probing monocyte forces with the C-Trap^® and acoustic force spectroscopy reveals CCL2 regulation of monocyte mechanics

LUMICKS’ C-Trap^® adopted by 8 teams in 3 multidisciplinary labs in France

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