A recent work published in eLife by Francisco de Asis Balaguer et al. shed light on the interaction of ParB with DNA, the consequent DNA condensation, and the role of cytidine triphosphate (CTP) in this process – at a single-molecule level. Using the C-Trap® the researchers investigated the role of…
The Technical University of Munich, Germany, is now the home of two C-Trap® Optical Tweezers – Fluorescence Microscopes. With this second installation, the renowned lab of Prof. Matthias Rief is taking their dynamic single-molecule research to the next level. Prof. Rief is a pioneer in studying processes involved in protein…
A recent study by Szu‐Ning Lin et al. for the first time provided direct information on the dynamics of the interaction between HU and DNA and how this interaction is influenced by ionic conditions and DNA conformation.
A recent publication by Kucera et al. in Nature Communications combined TIRF assays and Optical Tweezers measurements to investigate myosin-independent actin contraction that is relevant during cytokinesis and cell division. The authors found a new mechanism showing how anillin, a non-motor actin crosslinking and scaffolding protein, substitutes for the activity…
In a recent article published in Science Advances, researchers investigated the mechanical consequences of a missense mutation within a highly conserved region, P305L, in the kinesin motor family member A1 (KIF1A). By employing a single-molecule approach using the C-Trap® as well as biochemical and genetic assays, Lam et al. found…
We’re overjoyed to announce the placement of one of our most sophisticated C-Trap® systems at the newly formed Center for Optical Bio-Manipulation (COBM) at the Niels Bohr Institute, University of Copenhagen! The center is based around LUMICKS' C-Trap system, flaunting quadruple optical tweezers, 3 color confocal fluorescence microscopy, and STED…
We are delighted to announce two new C-Trap® installations in Europe, one at the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) and the other at the University of Kent. At MPI-CBG, this will be the second C-Trap installed. The new system is configured with quadruple optical traps…
A recent article published in the Journal of Physical Chemistry Letters provides insight into the stability and folding dynamics of RNA G-quadruplexes (RG4). Using the C-Trap® optical tweezers, Ye et al. investigated the influence of a proximal single-stranded (ss) RNA sequence and found that its existence significantly impairs RG4 stability.…
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