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AFS installed at LMT MunichBlog posts

New AFS™ installation at LMU

A new AFS™ Stand-alone was recently installed at Ludwig-Maximilians-Universität München in the Faculty of Physics. The Lab of Professor Jan Lipfert of the Chair for Biophysics and Molecular Materials will use the AFS™ to study the mechanosensitive response of multiple proteins in parallel. We wish Prof. Lipfert and his team success with the new…
Jerom Langeveld
19 April 2017
Multicolor detection of DNA overstretchingBlog posts

Multicolor Detection Application Note Now Online

Single-molecule force spectroscopy (SMFS) tools are widely used to study structural transitions of DNA during overstretching. However, as many of these tools only provide global information, the exact mechanisms that occur during these transitions remain unclear. Combining SMFS with visualization of local information could resolve this problem. Our Multicolor Detection application…
Jerom Langeveld
30 March 2017
optical tweezers dna repair force extension manipulation visualization RAD51 RecombinationBlog posts

Investigation of the Role of RAD52-DNA Complex in DNA Repair Using Optical Tweezers CTFM and Microfluidics

The article “Human RAD52 Captures and Holds DNA Strands, Increases DNA flexibility, and Prevents Melting of Duplex DNA: Implications for DNA Recombination” was recently published in Cell Reports. Congratulations to Dr. Ineke Brouwer and all co-authors! In this paper optical tweezers coupled with fluorescence microscopy and microfluidics were used to investigate…
Jerom Langeveld
24 March 2017
Blog posts

Study Published on DNA Compaction by Meiotic Protein SYCP3 using LUMICKS Technology

The article “Single-Molecule Observation of DNA Compaction by Meiotic Protein SYCP3” has recently been published in eLife Journal using optical tweezers-fluorescence microscopy. Congratulations to all the authors! In the paper by Syrjänen et al., optical tweezers-fluorescence microscopy was used to study the mechanism of SYCP3-mediated chromosome organization during meiosis, by…
Jerom Langeveld
16 March 2017
LUMICKS_AFS_installation_NUSBlog posts

LUMICKS’ AFS™ Installed at NUS

LUMICKS is happy to announce that an AFS™ system was installed at the National University of Singapore (NUS) in the lab of Professor Yan Jie. Professor Yan Jie and his group will use AFS™ along with their magnetic tweezers to research protein unfolding and DNA-protein interactions. We wish Professor Yan…
Jerom Langeveld
16 March 2017
Blog posts

Protein folding Application Note Now Online

The biological function of many macromolecules such as proteins and RNA are tightly coupled to their conformation and their conformational dynamic. The correct folding of a protein into its native state is essential for its biological function. Misfolded or unfolded proteins are known to be either (partially) inactive or to…
Jerom Langeveld
7 February 2017
C-Trap® Installed at ShanghaiTech UniversityBlog posts

C-Trap® Installed at ShanghaiTech University

LUMICKS is very excited to announce the first C-Trap® installation in Asia. The C-Trap® was installed at the lab of Assistant Professor Bo Sun at ShanghaiTech University in Shanghai, China. The group of Dr. Sun will use the C-Trap® to do a multitude of experiments involving DNA-protein interactions. His research…
Jerom Langeveld
6 February 2017
optical-tweezers-fibrin-fibersBlog posts

Effect of Mechanical Stress on Individual Vimentin Filaments Studied using the C-Trap®

The paper "Nonlinear Loading-Rate-Dependent Force Response of Individual Vimentin Intermediate Filaments to Applied Strain" using LUMICKS’ C-Trap® has recently been published in Physical Review Letters. Congratulations to all the authors! The study led by Prof. Sarah Köster, investigated the mechanical properties of the cytoskeleton in eukaryotic cells; and more specifically…
Jerom Langeveld
27 January 2017
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