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Imperial College London AFS installation atomic force spectroscopy

Blog posts

Imperial College London Acquires AFS™ System

At Imperial College London, LUMICKS has installed an AFS™ system! This is the first AFS™ in London, where it will be used in the lab of Prof. David Rueda. It will aid in imaging the interaction and dynamics of various nucleic acid enzymes (such as polymerases, the activation induced cytidine deaminase,…

Jerom Langeveld24 April 2017

Blog posts

New AFS™ installation at LMU

A new AFS™ Stand-alone was recently installed at Ludwig-Maximilians-Universität München in the Faculty of Physics. The Lab of Professor Jan Lipfert of the Chair for Biophysics and Molecular Materials will use the AFS™ to study the mechanosensitive response of multiple proteins in parallel. We wish Prof. Lipfert and his team success with the new…

Jerom Langeveld19 April 2017

Multicolor detection of DNA overstretching

Blog posts

Multicolor Detection Application Note Now Online

Single-molecule force spectroscopy (SMFS) tools are widely used to study structural transitions of DNA during overstretching. However, as many of these tools only provide global information, the exact mechanisms that occur during these transitions remain unclear. Combining SMFS with visualization of local information could resolve this problem. Our Multicolor Detection application…

Jerom Langeveld30 March 2017

optical tweezers dna repair force extension manipulation visualization RAD51 Recombination

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Investigation of the Role of RAD52-DNA Complex in DNA Repair Using Optical Tweezers CTFM and Microfluidics

The article “Human RAD52 Captures and Holds DNA Strands, Increases DNA flexibility, and Prevents Melting of Duplex DNA: Implications for DNA Recombination” was recently published in Cell Reports. Congratulations to Dr. Ineke Brouwer and all co-authors! In this paper optical tweezers coupled with fluorescence microscopy and microfluidics were used to investigate…

Jerom Langeveld24 March 2017

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Study Published on DNA Compaction by Meiotic Protein SYCP3 using LUMICKS Technology

The article “Single-Molecule Observation of DNA Compaction by Meiotic Protein SYCP3” has recently been published in eLife Journal using optical tweezers-fluorescence microscopy. Congratulations to all the authors! In the paper by Syrjänen et al., optical tweezers-fluorescence microscopy was used to study the mechanism of SYCP3-mediated chromosome organization during meiosis, by…

Jerom Langeveld16 March 2017

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LUMICKS’ AFS™ Installed at NUS

LUMICKS is happy to announce that an AFS™ system was installed at the National University of Singapore (NUS) in the lab of Professor Yan Jie. Professor Yan Jie and his group will use AFS™ along with their magnetic tweezers to research protein unfolding and DNA-protein interactions. We wish Professor Yan…

Jerom Langeveld16 March 2017

optical-tweezers-measure-DNA-replication-activity-states-with-force-fluorescence

Blog posts

Exonucleolysis and Replication by T7 DNA Polymerase Studied using Optical Tweezers and AFS™

The paper “Switching between Exonucleolysis and Replication by T7 DNA Polymerase Ensures High Fidelity” has recently been published in the Biophysical Journal using LUMICKS’ AFS™ technology and optical tweezers. We would like to congratulate all the authors! In the paper by Hoekstra et al., optical tweezers and AFS™ were used…

Jerom Langeveld8 March 2017

acoustic-force-spectroscopy-enzymatic-activity

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Acinetodin and Klebsidin Lasso Peptides Studied with AFS™ Technology

The first paper from one of our clients using AFS technology has been published in the journal ACS Chemical Biology led by prof. Mikhail Khodorkovskii. Congratulations to all the authors! In the paper named “Acinetodin and Klebsidin, RNA Polymerase Targeting Lasso Peptides Produced by Human Isolates of Acinetobacter gyllenbergii and…

Jerom Langeveld13 February 2017

Blog posts

Protein folding Application Note Now Online

The biological function of many macromolecules such as proteins and RNA are tightly coupled to their conformation and their conformational dynamic. The correct folding of a protein into its native state is essential for its biological function. Misfolded or unfolded proteins are known to be either (partially) inactive or to…

Jerom Langeveld7 February 2017

Blog posts

C-Trap^® Installed at ShanghaiTech University

LUMICKS is very excited to announce the first C-Trap® installation in Asia. The C-Trap® was installed at the lab of Assistant Professor Bo Sun at ShanghaiTech University in Shanghai, China. The group of Dr. Sun will use the C-Trap® to do a multitude of experiments involving DNA-protein interactions. His research…

Jerom Langeveld6 February 2017

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