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DNA BreathingBlog posts

DNA Breathing Application Note Now Online

DNA breathing, also known as fraying, describes the spontaneous local conformational transitions occurring within double-stranded DNA (dsDNA). Due to the transient and spontaneous nature of this process, the study of real-time DNA breathing transitions at the single-molecule level requires the use of highly sensitive experimentation technologies. Using LUMICKS’ high-resolution optical tweezers, small and transient DNA…
Jerom Langeveld
28 September 2017
strand-displacement polymerization investigated with u-Flux microfluidics microfluidics laminar flow cellBlog posts

Strand-Displacement Polymerization by Reverse Transcriptase Investigated using LUMICKS’ u-Flux™

The journal Nucleic Acids Research has recently published the paper "Pausing kinetics dominates strand-displacement polymerization by reverse transcriptase". We would like to congratulate the authors! Malik et al. (2017) used optical tweezers and, among other technologies, microfluidics to study the enzymatic activity of the murine leukemia Virus reverse transcriptase (RT). RT catalyzes the formation of an integration-competent double-stranded DNA…
Jerom Langeveld
26 September 2017
BIOCEV customer case story - Academy of Sciences of the Czech Republic, Faculty of Science and the First Faculty of Medicine of the Charles University in PragueBlog posts

Customer Case Story BIOCEV Prague

In January 2016, LUMICKS’ first C-Trap® Optical Tweezers-Fluorescence Microscopy instrument was successfully installed at the BIOCEV research center in the Czech Republic. BIOCEV is a research institute in the areas of biotechnology and biomedicine of both the Academy of Sciences of the Czech Republic and the Charles University. The instrument…
Jerom Langeveld
13 September 2017
cytoskeleton filament manipulation using optical tweezers fluorescence microscopyBlog posts

Filament Manipulation Application Note Now Online

Protein filaments have been studied indirectly using various approaches of fluorescence microscopy in cells and tissues and more directly, using force spectroscopy on single filaments or filament bundles. LUMICKS' C-Trap® provides for a unique approach which combines the strength of both techniques, to give a truly correlative method of studying…
Jerom Langeveld
6 September 2017
C-Trap Chemical Reviews AFS Biochemical Society TransactionsBlog posts

C-Trap® and AFS™ systems mentioned in two review articles

We are proud to announce that two review articles refer to LUMICKS; one highlighting the C-Trap® Optical Tweezers-Fluorescence Microscopy system and the other one specifying the AFS™ Acoustic Force Spectroscopy system.  Norregaard et al. (2017) reviews relevant theoretical tools to analyze data obtained from single-molecule experiments performed in intracellular environments and describes state-of-the art visualization techniques…
Jerom Langeveld
6 July 2017
Acoustic force spectroscopy Pasteur Institute Paris Thierry RoseBlog posts

AFS™ Installed at Pasteur Institute in Paris

The first  AFS™ system in France has been successfully installed at the lab of Dr. Thierry Rose at the Pasteur Institute in Paris. Dr. Rose and his team use AFS to manipulate human lymphocytes in living conditions to gain insights in the early steps of cytokine-induced signaling and how this…
Jerom Langeveld
16 June 2017
Top banner image was licensed by Daniel Schwen / Wikimedia Commons.Blog posts

New C-Trap® acquired by the University of Göttingen

A new C-Trap® system has recently been acquired by the Georg August University in Göttingen, Germany. The C-Trap® was successfully installed in the lab of the “Nanoscale Imaging of Cellular Dynamics” research group, led by Prof. Dr. Sarah Köster, at the Institute for X-Ray Physics. The optical tweezers-fluorescence microscopy system will be…
Jerom Langeveld
7 June 2017
Acoustic Force Spectroscopy Protein Unfolding Application Note high throughputBlog posts

AFS Protein Unfolding Application Note Now Online

Single-molecule force spectroscopy (SMFS) technologies have become prominent as powerful tools for the investigation of the biomechanics associated with protein structure and for the study of protein unfolding pathways. However, current SMFS tools lack the ability to study multiple protein (un)folding events simultaneously, making the investigation of protein folding an…
Jerom Langeveld
10 May 2017
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