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cytoskeleton filament manipulation using optical tweezers fluorescence microscopyBlog posts

Filament Manipulation Application Note Now Online

Protein filaments have been studied indirectly using various approaches of fluorescence microscopy in cells and tissues and more directly, using force spectroscopy on single filaments or filament bundles. LUMICKS' C-Trap® provides for a unique approach which combines the strength of both techniques, to give a truly correlative method of studying…
Jerom Langeveld
6 September 2017
C-Trap Chemical Reviews AFS Biochemical Society TransactionsBlog posts

C-Trap® and AFS™ systems mentioned in two review articles

We are proud to announce that two review articles refer to LUMICKS; one highlighting the C-Trap® Optical Tweezers-Fluorescence Microscopy system and the other one specifying the AFS™ Acoustic Force Spectroscopy system.  Norregaard et al. (2017) reviews relevant theoretical tools to analyze data obtained from single-molecule experiments performed in intracellular environments and describes state-of-the art visualization techniques…
Jerom Langeveld
6 July 2017
Acoustic force spectroscopy Pasteur Institute Paris Thierry RoseBlog posts

AFS™ Installed at Pasteur Institute in Paris

The first  AFS™ system in France has been successfully installed at the lab of Dr. Thierry Rose at the Pasteur Institute in Paris. Dr. Rose and his team use AFS to manipulate human lymphocytes in living conditions to gain insights in the early steps of cytokine-induced signaling and how this…
Jerom Langeveld
16 June 2017
Top banner image was licensed by Daniel Schwen / Wikimedia Commons.Blog posts

New C-Trap® acquired by the University of Göttingen

A new C-Trap® system has recently been acquired by the Georg August University in Göttingen, Germany. The C-Trap® was successfully installed in the lab of the “Nanoscale Imaging of Cellular Dynamics” research group, led by Prof. Dr. Sarah Köster, at the Institute for X-Ray Physics. The optical tweezers-fluorescence microscopy system will be…
Jerom Langeveld
7 June 2017
Acoustic Force Spectroscopy Protein Unfolding Application Note high throughputBlog posts

AFS Protein Unfolding Application Note Now Online

Single-molecule force spectroscopy (SMFS) technologies have become prominent as powerful tools for the investigation of the biomechanics associated with protein structure and for the study of protein unfolding pathways. However, current SMFS tools lack the ability to study multiple protein (un)folding events simultaneously, making the investigation of protein folding an…
Jerom Langeveld
10 May 2017
Imperial College London AFS installation atomic force spectroscopyBlog posts

Imperial College London Acquires AFS™ System

At Imperial College London, LUMICKS has installed an AFS™ system! This is the first AFS™ in London, where it will be used in the lab of Prof. David Rueda. It will aid in imaging the interaction and dynamics of various nucleic acid enzymes (such as polymerases, the activation induced cytidine deaminase,…
Jerom Langeveld
24 April 2017
AFS installed at LMT MunichBlog posts

New AFS™ installation at LMU

A new AFS™ Stand-alone was recently installed at Ludwig-Maximilians-Universität München in the Faculty of Physics. The Lab of Professor Jan Lipfert of the Chair for Biophysics and Molecular Materials will use the AFS™ to study the mechanosensitive response of multiple proteins in parallel. We wish Prof. Lipfert and his team success with the new…
Jerom Langeveld
19 April 2017
Multicolor detection of DNA overstretchingBlog posts

Multicolor Detection Application Note Now Online

Single-molecule force spectroscopy (SMFS) tools are widely used to study structural transitions of DNA during overstretching. However, as many of these tools only provide global information, the exact mechanisms that occur during these transitions remain unclear. Combining SMFS with visualization of local information could resolve this problem. Our Multicolor Detection application…
Jerom Langeveld
30 March 2017
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