Revealing biomolecular insights never before available
Molecular mechanisms are at the heart of understanding biology
All biological processes ultimately take place at the molecular level, all diseases arise at this level, and practically all drugs act at this level. However, many life science and tools that are used today to approximate and extract molecular function such as structural biology, bulk functional assays, cell imaging, and localization assays, give either detailed structural or functional information - but rarely both.
Unable to observe molecular processes in real time, they often fail to reveal crucial mechanistic details of the molecular factors at play. This lack of direct observation of the underlying dynamic processes often results in ambiguous data, not suited to deliver clear insights.
Dynamic Single-Molecule, the missing link
What if you could measure molecular properties and interactions while simultaneously recording and showing you the processes in real-time? A technology that can reveal the crucial and dynamic interactions taking place at the molecular level and gives you direct proof of the mechanisms involved. A tool that can provide an understanding of the root of disease development at the molecular level and accelerate therapeutic breakthroughs.
Dynamic Single-Molecule combines live visualization, manipulation, and force measurement at the smallest molecular scale, leads to single-molecule imaging and base-pair resolution measurements of the interactions between biomolecules. Taken together, this provides – for the first time – the crucial dynamic and functional mechanistic information that is complementary to molecular structure, bulk functional assays, and cell imaging.
Dynamic Single-Molecule combines live visualization, manipulation, and force measurement at the smallest molecular scale, leads to single-molecule imaging and base-pair resolution measurements of the interactions between biomolecules. Taken together, this provides – for the first time – the crucial dynamic and functional mechanistic information that is complementary to molecular structure, bulk functional assays, and cell imaging.
Gain unprecedented insights into the complex mechanistic details of interactions
Correlate structure and function like no other technology can do
Get started up in no time through the easy to use workflow and solutions
Workflow
The Dynamic Single-Molecule workflow
Let’s take you through the various steps involved in an experiment
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Applications
Explore your research application
Explore what Dynamic Single-Molecule can mean for your field of interest
DNA-Binding Proteins
DNA Replication
Study and visualize DNA replication mechanisms at the nanoscale
Use Dynamic Single-Molecule to obtain the full understanding of replication mechanisms
Available case studies:
Shed light on the role of SMC5/6 in regulating replication fork stability
Case study
Real-time insights into origin recognition and replisome formation
Case study
Replication in context: Uncover mechanisms ensuring replication fidelity and genome stability
Case study
DNA Transcription
Study and visualize DNA transcription mechanisms at the nanoscale
Use Dynamic Single-Molecule to obtain the full understanding of transcription mechanisms
Available case studies:
Real-time observation of DNA exonuclease dynamics at base-pair level
Case study
DNA Repair
Study and visualize DNA repair processes at the nanoscale
Use Dynamic Single-Molecule to obtain the full understanding of repair mechanisms
Available case studies:
Revealing molecular mechanism heterogeneity in UV-DDB-related DNA repair processes
Case study
Visualizing DNA translocation and lesion recognition
Case study
Revealing the facilitation of DNA repair through PARP1 condensation
Case study
DNA Organization
Discover the mechanisms and roles of chromatin organization and decipher the epigenetic code
Use Dynamic Single-Molecule to obtain the full understanding of organization mechanisms
Available case studies:
Quantify SMC activity, conformation and interactions at the molecular level
Case study
Follow chromatin remodeler activity in real-time
Case study
Quantify nucleosome stability and cross-linking
Case study
DNA/RNA Structure
Reveal the structural dynamics of RNA & DNA in real time
Use Dynamic Single-Molecule to obtain the full understanding of DNA/RNA structure
Available case studies:
Revealing stability and dynamics of telomeric G-quadruplexes
Case study
Elucidating toxic RNA misfolding dynamics in Huntington’s disease
Case study
Protein-mediated frameshift regulation in SARS-CoV-2
Case study
DNA Editing
Study and visualize DNA editing mechanisms on the nanoscale
Use Dynamic Single-Molecule to obtain the full understanding of editing mechanisms
Available case studies:
Understand off-target activities of Cas for safer gene editing
Case study
Real-time insights into gene editing mechanisms
Case study
Mechanobiology
Uncover mechanical principles of cellular function at the molecular level
Available case studies:
Kinetochore-mediated chromosome segregation
Case study
Cellular tension propagation revisited
Case study
Cellular droplet fusion and small components in a multicellular organism
Case study
Phase Separation
From fundamental mechanism to biological function – explore biomolecular condensates across scales
Available case studies:
Variations in low-complexity domains and how they influence protein droplet solidification
Case study
The effect of molecular crowders on droplet fusion
Case study
The effect of RNA/RNP interactions on the fusion of protein droplets
Case study
Cytoskeletal Structure and Transport
Study cytoskeletal motors in real-time at the nanoscale
Available case studies:
Investigation of motor protein stepping mechanics along cytoskeletal filaments
Case study
Stepping of filaments and motors at the surface
Case study
Force-extension, manipulation, and visualization of polymers and protein filaments
Case study
Protein Folding
Study protein folding and conformational dynamics at the nanoscale
Available case studies:
Study of multi-domain protein folding & conformational dynamics
Case study
Solutions
C-Trap
Biomolecular interactions re-imagined
The C-Trap® provides the world’s first dynamic single-molecule microscope to allow simultaneous manipulation and visualization of single-molecule interactions in real time.
Technical note:
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There is a hidden collection to add multiple authors to this publication.
This section is hidden when emtpy.
To keep everything visible here, that is being done outside the webflow designer from within Slater.
Text Link
GAGA zinc finger transcription factor searches chromatin by 1DÐ3D facilitated diffusion
Feng, X. A. et al.
2025
Nature Structural & Molecular Biology
Text Link
Substrate accessibility regulation of human TopIIa decatenation by cohesin
Cutts, E. E. et al.
2025
Nature Communications
Text Link
Homotypic RNA clustering accompanies a liquid-to-solid transition inside the core of multi-component biomolecular condensates
Mahendran, T. S. et al.
2025
Nature Chemistry
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