Accelerating DNA-protein interaction experiments with nuclear extracts in the C-Trap

Title
Accelerating DNA-protein interaction experiments with nuclear extracts in the C-Trap
Reading time
15 min
Collaborators
Prof. Bennett Van Houten, University of Pittsburgh
Topics

DNA-binding proteins

Download now

Dive into the cutting-edge fusion of nuclear extracts and dynamic single-molecule (DSM) analysis in LUMICKS’ C-Trap. This approach revolutionizes how DNA-protein interactions are studied, offering unmatched biological relevance and accessibility. Biology researchers eager to unravel the complexities of nuclear processes will find this application note a game-changer. Explore how the C-Trap elevates molecular biology research to unprecedented heights.

Key Learning Points:

  • How to observe DNA-binding proteins in their natural state, complete with post-translational modifications, for insights previously inaccessible through purified protein assays.
  • How to leverage standard mammalian cell culture techniques to perform sophisticated single-molecule experiments without extensive biochemistry expertise.
  • How to visualize dynamic protein-DNA interactions, co-localization, and diffusion in real-time, uncovering mechanisms critical to DNA repair, replication, and transcription.
Title
Accelerating DNA-protein interaction experiments with nuclear extracts in the C-Trap
Reading time
15 min
Collaborators
Prof. Bennett Van Houten, University of Pittsburgh
Topics

DNA-binding proteins

Download now

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