Application Notes

Unlock the true potential of CRISPR Cas9 technology through real-time direct visualization of Cas9 gene-editing

CRISPR Cas9 is a gene editing tool that has increased in popularity due to its simplicity to use. It allows researchers to seamlessly edit DNA sequences by combining a sequence identifying guide RNA (gRNA) with the Cas9 endonuclease enzyme. However, its applicability as a gene-editing and therapeutic tool is impeded…

Adrià Ferragut27 October 2023

Single-molecule visualisation of DNA repair mechanisms and non-homologous end joining (NHEJ)

DNA repair, the collection of highly regulated mechanisms by which a cell identifies and repairs DNA damage, remains one of the most essential processes of human life. Impaired DNA repair systems may lead to malignant mutations that jeopardize cellular well-being. To study DNA repair, single-molecule studies have proven to greatly…

Adrià Ferragut27 October 2023

Optical tweezers combined with STED reveals protein dynamics on densely covered DNA

Today’s quantitative analysis of DNA-protein interactions at the single-molecule level requires the capability of measuring under biologically relevant conditions with high temporal resolution. This problem can especially be observed when in vitro experiments are linked with the in vivo situation in which proteins interact highly dynamic with DNA at high…

Adrià Ferragut27 October 2023

Manipulate and study protein droplet dynamic and properties in realtime to understand phase separation

In this application note, we highlight multiple experiments conducted at Banerjee Lab at the University at Buffalo, and Hyman Lab at the Max Planck Institute of Molecular Cell Biology and Genetics on phase separation using the C-Trap dynamic single molecule technology. We present the two approaches the studies used to…

Adrià Ferragut27 October 2023

Dynamic single-molecule analysis offers invaluable insights into DNA repair mechanisms: HELQ in DSB case study

DNA repair is a highly complex and dynamic process that involves the interplay of numerous different proteins and components. The helicase HELQ is known to play a role in double-stranded breaks (DSBs) repair, but its molecular mechanisms remain unknown. A study by the research group led by Simon Boulton presented…

Adrià Ferragut27 October 2023

Cell avidity measurement: a new accurate method to predict in vivo CAR T cell efficacy and minimize drug discovery timelines

In this application note, we describe the power of cell avidity in the search for improved CAR T cell therapies. We report on two publications from the lab of Dr. Marcela V. Maus (Harvard Medical School) that illustrate how cell avidity measurement with the z-Movi Cell Avidity Analyzer can accelerate…

getyos14 September 2023

Increased cell avidity through CD38 co-receptor drives enhanced BCMA CAR T-cell sensitivity and persistence in multiple myeloma

In this research highlight, we present cell avidity results obtained with the z-Movi® Cell Avidity Analyzer in collaboration with the team of Dr. Maria Themeli (VUMC Cancer Center Amsterdam) working on BCMA + CD38 dual-targeting CAR T therapy against multiple myeloma. Key learning points: Cell avidity measurements with the z-Movi…

getyos14 September 2023

Identify functionally optimal TCR-engineered T cells through cell avidity measurements

In this application note, we present cell avidity obtained with the z-Movi® Cell Avidity Analyzer and in vitro experiments performed in collaboration with the team of Dr. Nathalie Rufer (University of Lausanne). Here you will learn: 1. In contrast to affinity measured by SPR, cell avidity measurements directly correlate with…

getyos14 September 2023

Rapid assessment of CAR T-cell therapy strategies for multiple myeloma with the cell avidity analysis

In this application note, we highlight cell avidity and in vivo experiments performed in collaboration with the team of Dr. Eric Smith (DanaFarber Cancer Institute) and Prof. Carlos de Larrea (Hospital Clínic Barcelona) and show how one can use the z-Movi Cell Avidity Analyzer to: 1. Rapidly identify new, effective…

getyos14 September 2023

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Company and Science news

Unlock the true potential of CRISPR Cas9 technology through real-time direct visualization of Cas9 gene-editing

Single-molecule visualisation of DNA repair mechanisms and non-homologous end joining (NHEJ)

Optical tweezers combined with STED reveals protein dynamics on densely covered DNA

Manipulate and study protein droplet dynamic and properties in realtime to understand phase separation

Dynamic single-molecule analysis offers invaluable insights into DNA repair mechanisms: HELQ in DSB case study

Cell avidity measurement: a new accurate method to predict in vivo CAR T cell efficacy and minimize drug discovery timelines

Increased cell avidity through CD38 co-receptor drives enhanced BCMA CAR T-cell sensitivity and persistence in multiple myeloma

Identify functionally optimal TCR-engineered T cells through cell avidity measurements

Rapid assessment of CAR T-cell therapy strategies for multiple myeloma with the cell avidity analysis

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