Identify functionally optimal TCR-engineered T cells through cell avidity measurements
In this application note, we present cell avidity obtained with the z-Movi® Cell Avidity Analyzer and in vitro experiments performed in collaboration with the team of Dr. Nathalie Rufer (University of Lausanne). Here you will learn:
- In contrast to affinity measured by SPR, cell avidity measurements directly correlate with T-cell functionality.
- Avidity is a reliable parameter for the selection of top TCR candidates.
- Cell avidity measurements with the z-Movi can accelerate the characterization of TCR-engineered T cells with anti-tumor activity and immunotherapeutic potential, through a fast and high-throughput workflow.
Download a copy of the application note here on the right to discover how you can perform cell avidity analysis assessment to explore and validate TCR T-cell functionality and obtain predictive, reproducible, and rapid results at the single-cell level without compromising cell viability.
