DNA Repair Visualization Application Note Now Online

DNA repair, the collection of highly-regulated mechanisms by which a cell identifies and repairs DNA damage, remains one of the most essential processes of human life. Without DNA repair mechanisms cells lose the ability to transcribe important regions of their … Continue Reading

Protein Unfolding Application Note Now Online

The biological function of many macromolecules such as proteins and RNA are tightly coupled to their conformation and their conformational dynamic. The correct folding of a protein into its native state is essential for its biological function. Misfolded or unfolded … Continue Reading

STED Application Note Now Online

Today’s quantitative analysis of DNA-protein interactions at the single-molecule level requires the capability of measuring under biologically relevant conditions with high temporal resolution. This problem can especially be observed when in vitro experiments are linked with the in vivo situation … Continue Reading