Acoustic force spectroscopy for cell analysis

How does the z-Movi technology work?

How does it work in practice? It all starts with the Acoustic Force Spectroscopy principle At the heart of the z-Movi technology, inside the microfluidic chip, you will find the piezo element that generates resonant acoustic waves. These ultrasound waves are the foundation of cell avidity analyses, as they can pull cells vertically toward the…
Erica Fong
11 November 2021

IRM (label-free)

What is IRM microscopy? Interference reflection microscopy (IRM) is an optical microscopy technique that takes advantage of polarized light to form an image of an object on a glass surface1-2. The intensity of the signal is a measure of the proximity of the object to the glass surface. This technique…
Ron Eliyahoo
16 November 2021


What is TIRF microscopy? Total internal reflection fluorescence (TIRF) microscopy excites fluorophores in a thin region of the sample1. Only fluorescent molecules that are close to the solid (usually the surface of a glass coverslip) are efficiently excited. This enables you to visualize surface-bound molecules or cells with high resolution.…
Ron Eliyahoo
17 November 2021
Immune synapse cell avidity and cell killing

What is an immune synapse?

Understanding the synaptic interactions through cell avidity measurements An immune (or immunological) synapse is the interface between a cancer and a T cell, which is formed in a highly stable, organized manner. This interface can also be formed between cancer cells and other effector cells, such as natural killer cells. The immune synapse is composed of…
Taylor Yerbury
24 February 2021

STED Super Resolution

What is STED nanoscopy? Stimulated emission depletion (STED) is a fluorescence microscopy technique that facilitates visualization of sub-cellular organization with unprecedented detail. Stefan Hell, the person who created STED, got the Nobel Prize in Chemistry in 2014 for this invention. STED can achieve super-resolution, bypassing the diffraction limitations of confocal…
Ron Eliyahoo
21 July 2021
Cell avidity: a new biomarker for IO research

What is avidity and why is it important?

The missing biomarker in immuno-oncology Binding events between a T cell and its target tumor cell determine the initiation of immunological synapse formation. This in turn sets a series of important events in motion, such as T-cell activation, T-cell expansion, tumor cell elimination and persistence. These events are all a function of the…
Taylor Yerbury
19 February 2021


What is confocal microscopy? The confocal microscope scans a laser beam through a sample to excite molecules that are in focus. The molecules then emit photons, which are measured by a detector. A pinhole in front of the detector blocks out-of-focus light and hence improves image quality. Confocal microscopy offers…
Taylor Yerbury
19 February 2021
correlated Optical Tweezers - Fluorescence Microscopy

Correlated optical tweezers with fluorescence microscopy

Correlative optical tweezers with fluorescence (CTFM) is a dynamic single-molecule technique that combines optical tweezers, fluorescence microscopy, and microfluidics into a fully integrated platform. It can be used to apply and measure forces while simultaneously visualizing individual molecules in real-time. With this technology it is possible to perform simultaneous manipulation,…
Taylor Yerbury
19 February 2021


What is widefield microscopy? Similar to brightfield microscopy, widefield fluorescence microscopy illuminates the sample from below. The difference is in the light. Instead of a white light, fluorescence microscopy uses light of frequencies that can excite fluorescent molecules associated to your sample. With the widefield fluorescence microscopy technique, you illuminate…
Taylor Yerbury
19 February 2021

What are optical tweezers?

What are optical tweezers and what can they do? In 2018 Arthur Ashkin won the Nobel Prize in Physics "for the optical tweezers and their application to biological systems". In essence, he discovered that light's momentum could serve as an incredibly sensitive set of tweezers to catch and study biomolecules.By…
Taylor Yerbury
18 February 2021

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