Webinars

Monthly webinar series In this online seminar series, we review the biological principles behind immunotherapy and how measurements of cell avidity may be used as a functional biomarker to help fundamentally improve cell therapy development. Immuno-oncology digests #6: Tight regulation of co-stimulatory signals and how that determines CD8+ T cell…
Doenja Jansen
4 January 2022

网络研讨会(中国大陆链接)

每月网络研讨会系列 In this online seminar series, we review the biological principles behind immunotherapy and how measurements of cell avidity may be used as a functional biomarker to help fundamentally improve cell therapy development. Immuno-oncology digests #3: New insights into downstream CAR-T cell function NEW In this webinar, we will address…
Doenja Jansen
22 March 2022

Webinars

Keynote speaker webinars Seminars from world-leading experts With worldwide efforts to limit movement, we strive to continue delivering scientific content and enabling scientists within the dynamic single-molecule community. That’s why we’ve gathered the newest innovations to arrange thought-provoking and interactive presentations with expert speakers. Northeastern University Quantifying binding and movement…
Taylor Yerbury
4 January 2022

网络研讨会(中国大陆链接)

主讲人网络研讨会 世界领先专家们的科学分享 随着全球范围内旅行的缩紧,我们努力继续提供科学内容,并为单分子科学领域的科学家提供支持。 我们举办了很多和专家的线上研讨会,并收集在这里,与您一起分享专家演讲者们在科学领域的风采。 Northeastern University Quantifying binding and movement of proteins along DNA HKUST Combining optical tweezers microscopy and surface-enhanced Raman spectroscopy (SERS) to characterize protein structures CIC nanoGUNE Nanomechanics of biological systems: from single-proteins to single-cells Chinese Academy of Sciences Single-molecule force spectroscopy of protein-membrane interactions University of…
Taylor Yerbury
17 March 2022

Application notes and research highlights

Discover our application notes and research highlight on cell avidity below: Rapid assessment of CAR T-cell strategies for multiple myeloma with the z-Movi® Cell Avidity Analyzer In this application note, we highlight cell avidity and in vivo experiments performed in collaboration with the team of Dr. Eric Smith (DanaFarber Cancer…
Taylor Yerbury
4 January 2022

Applications notes

Explore a range of our applications within our dynamic single-molecule application field Analyze Cas9 binding and cleavage properties in real-time while manipulating DNA structures (English) | (中文) Deciphering the structure-function relationship of RNA: a complete guide (English) | (中文) Optical tweezer measurements of DNA conformational dynamics at the single-molecule level…
Taylor Yerbury
4 January 2022

Publications

Explore a range of publications within our dynamic single-molecule application field Anand, R. et al. HELQ is a dual-function DSB repair enzyme modulated by RPA and RAD51. Nature 2021 Paul, B. et al. Mechanics of CRISPR-Cas12a and engineered variants on λ-DNA. Nucleic Acids Research 2021 Hill, C. H. et al. Structural and molecular basis for Cardiovirus 2A protein as…
Taylor Yerbury
4 January 2022

Drug research

How dynamic single-molecule analysis contributes to drug research One of the big challenges in drug discovery today is that all current life science tools working at the molecular level either measure static structure or average binding kinetics; the crucial and often very complex mechanical details of the underlying dynamic process are often not…
Doenja Jansen
4 January 2022

Publications

Cell avidity publications Leick et al. Non-cleavable hinge enhances avidity and expansion of CAR-T cells for acute myeloid leukemia. Cancer Cell, 2022. Larson et al. CAR T cell killing requires the IFNγR pathway in solid but not liquid tumours. Nature, 2022 Halim et al. Engineering of an avidity-optimized CD19-specific parallel chimeric antigen receptor…
Taylor Yerbury
4 January 2022

The z-Movi workflow

The z-Movi workflow We've optimized the z-Movi workflow to facilitate excellent user experience and provide you with reliable and reproducible results in a matter of minutes. The z-Movi Chip is made to simplify cell culturing and maintain your samples in physiological conditions while you perform experiments. Once you have performed…
Erica Fong
23 November 2021

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