Webinars

Monthly webinar series Are you keen to dive deep into various topics related to immuno-oncology? Dr. Rogier Reijmers, Principal Scientist and Head of Research Validation at LUMICKS, will kick off the opening webinar with the concept of cell avidity and what it can mean for the development of cellular immunotherapies. The webinar…
Doenja Jansen
4 January 2022

Webinars

Keynote speaker webinars Seminars from world-leading experts With worldwide efforts to limit movement, we strive to continue delivering scientific content and enabling scientists within the dynamic single-molecule community. That’s why we’ve gathered the newest innovations to arrange thought-provoking and interactive presentations with expert speakers. Below are our three of our…
Taylor Yerbury
4 January 2022

Application notes

Discover our application notes on cell avidity below: Rapid assessment of CAR T-cell strategies for multiple myeloma with the z-Movi® Cell Avidity AnalyzerIdentify functionally optimal TCR-engineered T cells through cell avidity measurements Our solution The z-Movi® Cell Avidity Analyzer is a solution for researchers to determine cell avidity, which has been notoriously difficult…
Taylor Yerbury
4 January 2022

Applications notes

Explore a range of our applications within our dynamic single-molecule application field Analyze Cas9 binding and cleavage properties in real-time while manipulating DNA structures Deciphering the structure-function relationship of RNA: a complete guide Optical tweezer measurements of DNA conformational dynamics at the single-molecule level Real-time visualization of DNA structural transitions…
Taylor Yerbury
4 January 2022

Publications

Explore a range of publications within our dynamic single-molecule application field Zhang, Q. et al. Efficient DNA interrogation of SpCas9 governed by its electrostatic interaction with DNA beyond the PAM and protospacer. Nucleic Acids Research, 2021. Buzón, P. et al. Virus self-assembly proceeds through contact-rich energy minima. Science Advances, 2021. Davis, R. B. et al. FUS…
Taylor Yerbury
4 January 2022

Drug research

How dynamic single-molecule analysis contributes to drug research One of the big challenges in drug discovery today is that all current life science tools working at the molecular level either measure static structure or average binding kinetics; the crucial and often very complex mechanical details of the underlying dynamic process are often not…
Doenja Jansen
4 January 2022

Publications

Cell avidity publications Katsarou et al. Dual targeting with a CAR and a chimeric costimulatory receptor (CCR) enhances T cell sensitivity of tumor antigen recognition and persistence. Science Translational Medicine, 2021. Fernandez de Larrea et al. Defining an Optimal Dual-Targeted CAR T-cell Therapy Approach Simultaneously Targeting BCMA and GPRC5D to Prevent…
Taylor Yerbury
4 January 2022

The z-Movi workflow

The z-Movi workflow We've optimized the z-Movi workflow to facilitate excellent user experience and provide you with reliable and reproducible results in a matter of minutes. The z-Movi Chip is made to simplify cell culturing and maintain your samples in physiological conditions while you perform experiments. Once you have performed…
Erica Fong
23 November 2021
Acoustic force spectroscopy for cell analysis

How does the z-Movi technology work?

How does it work in practice? It all starts with the Acoustic Force Spectroscopy principle At the heart of the z-Movi technology, inside the microfluidic chip, you will find the piezo element that generates resonant acoustic waves. These ultrasound waves are the foundation of cell avidity analyses, as they can pull cells vertically toward the…
Erica Fong
11 November 2021

The role of forces in biology

The nature and study of forces in biology Cells communicate in two primary methods: electrochemical signals (which dictate cell proliferation, adhesion, migration, and reproduction) and direct forces (such as DNA transduction, binding, or repair). Studies of cellular mechanical properties and their environments are a rapidly growing area of interest amongst drug…
Ron Eliyahoo
16 November 2021

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