Observe your protein on DNA in real-time to directly bridge between its molecular mechanism and its clinical impact

Understanding how DNA-binding proteins interact with DNA is key (add CTA)

The vast majority of biological processes occur at the molecular level with DNA-binding proteins at their core. This is where diseases arise and most drugs act. Therefore, understanding the molecular mechanisms at play is crucial

Current methods often lack the ability to reveal the dynamic molecular mechanism of individual proteins on DNA (make a copy content of this, that is then accessible through a CTA, instead of showing here)

The broad range of available life science tools provides diverse information on the investigated biological systems. By combining many methods with their own advantages and drawbacks, the protein’s molecular function can be inferred. However, these methods are often unable to reveal some of the crucial mechanistic details that are only accessible when looking dynamically, in real-time, at the single-molecule level while having great experimental control. What if a method exists that fulfills all these requirements?

Dynamic single-molecule methods for direct, indisputable proof of the detailed molecular mechanisms

Looking directly at how a single protein interacts on a single DNA, in-real time, dynamically, while having complete control over the experimental conditions uniquely sheds light on the protein’s molecular mechanism. Dynamic single-molecule methods are able to accomplish this. They allow you to get direct, indisputable proof of the molecular mechanisms, leading you in no time to highly impactful discoveries.

The C-Trap® is the world’s first dynamic single-molecule instrument designed to capture detailed DNA-binding protein interactions in real-time, effortlessly 

Directly visualize the dynamics of individual proteins in real-time

Control and observe the stepwise assembly of the biological complex

Modulate the molecular system to test the model under different conditions.

Designed for user friendliness, the C-Trap combines optical tweezers, fluorescence microscopy and microfluidics control within a single fully integrated instrument that result in the fastest, most reliable and most impactful approaches for interrogating DNA-binding protein molecular mechanisms. Users without relevant background expertise are trained within a week, and publish new groundbreaking work within 9 months. See the workflow in action!

We are trusted around the world by key opinion leaders that are already using the C-Trap to conduct highly impactful science

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> 100 customers
> 100 publications
> 13.3 impact factor

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