Observe your protein on DNA in real-time to directly bridge between its molecular mechanism and its clinical impact
That is the dream, isn’t it?
Learn how you can get one step closer to achieving this, like 50 other leading institutes worldwide are already doing
Download this brochure for more information!
Understanding how DNA-binding proteins interact with DNA is key
The vast majority of biological processes occur at the molecular level with DNA-binding proteins at their core. This is where diseases arise and most drugs act. Understanding the molecular mechanisms at play is therefore crucial. Take the example below of PARP, a DNA repair protein widely known for being a target in cancer therapies. A recent study highlighted its synergistic molecular mechanism with POLQ and suggested how POLQ could therefore act as a second cancer therapy target.
Watch this 60s summary video
Current methods often lack the ability to reveal the dynamic molecular mechanism of individual proteins on DNA
The broad range of available life science tools provides diverse information on the investigated biological systems. By combining many methods with their own advantages and drawbacks, the protein’s molecular function can be inferred through its detailed static structure or average behavior. However, these methods are often unable to reveal some of the crucial mechanistic details that are only accessible when looking dynamically, in real-time, at the single-molecule level while having great experimental control. What if a method exists that fulfills all these requirements?
Dynamic single-molecule methods for direct, indisputable proof of the detailed molecular mechanisms
Dynamic single-molecule methods allows you to directly look at how a single protein interacts on a single DNA, in-real time, dynamically, while having complete control over the experimental conditions. This uniquely sheds light on the protein’s molecular mechanism. The C-Trap® is the world’s first dynamic single-molecule instrument designed to capture detailed DNA-binding protein interactions in real-time, effortlessly, leading you in no time to highly impactful discoveries.
Directly visualize the dynamics of individual proteins in real-time
Control and observe the stepwise assembly of the biological complex
Modulate the molecular system to test the model under different conditions.
Designed for user friendliness, the C-Trap combines optical tweezers, fluorescence microscopy and microfluidics control within a single fully integrated instrument that result in the fastest, most reliable and most impactful approaches for interrogating DNA-binding protein molecular mechanisms.
Download the C-Trap brochure to learn more!
We are trusted worldwide by key opinion leaders that are already using the C-Trap to conduct highly impactful science
