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Single-molecule study assesses how cohesin complexes bridge DNA molecules using C-Trap® correlated optical tweezers with fluorescence microscopy

In a new study published in the journal Science Advances, Gutierrez-Escribano et al. studied the role of cohesin complexes in DNA tethering to gain a better understanding of sister chromatid cohesion. Using the C-Trap correlated optical tweezers with fluorescence microscopy, they observed in real-time intermolecular (DNA–DNA) and intramolecular cohesin-derived DNA bridge…
Santiago Gisler
5 December 2019
Top banner image was licensed by The University of Vermont / Flickr.Uncategorised

C-Trap® installed at University of Vermont

We are happy to announce the recent installation of the C-Trap™ at the University of Vermont Larner College of Medicine. Several labs will use the correlated optical tweezers – fluorescence microscopy instrument to investigate the dynamics of molecular machines that interact with their tracks to generate force and motion. These processes are…
Santiago Gisler
22 October 2019
C-Trap Albert Einstein College of MedicineUncategorised

C-Trap® installed at Albert Einstein College of Medicine

We are happy to announce the installation of the C-Trap™ at the Albert Einstein College of Medicine in New York in the lab of Prof. Dr. Arne Gennerich. The instrument combines optical tweezers with 3-color total internal reflection fluorescence (TIRF; a technology that reduces fluorescence background noise in surface-based assays)…
Santiago Gisler
1 October 2019
New C-Trap™ Installed at the University at BuffaloUncategorised

Study establishes molecular forces responsible for condensation of ribonucleoprotein-RNA complexes

Researchers investigated the molecular driving forces underlying the condensation and decondensation of ribonucleoproteins using the C-Trap™. Specifically, they showed that sequence-dependent features of the RNA and ribonucleoprotein molecules partially dictate phase transitions. These findings can help scientists further understand the properties underlying eukaryotic liquid-liquid phase separation, or formation of membrane-less…
Santiago Gisler
5 September 2019
AFSUncategorised

New study maps internal and external structures of red blood cell aggregates by combining AFS® and 3D imaging

Researchers used acoustic force spectroscopy (AFS™) in combination with 3D imaging to induce clustering and rotation of red blood cells, enabling them to study the properties of cell aggregates. The new approach, which is based on radiation and stream forces, allows researchers to retrieve 3D reconstructions of biologically relevant conditions…
Santiago Gisler
29 August 2019
Uncategorised

New study evaluates the dynamics behind viral assembly at the single-molecule level using both C-Trap™ and AFS®

Researchers used the C-Trap™ optical tweezers – fluorescence microscopy system and acoustic force spectroscopy (AFS) to study the processes underlying viral assembly. The study evaluated the capsid formation and DNA condensation of virus-like particles (VLPs) at the single-molecule level and in real time. The results serve to expand our understanding…
Santiago Gisler
22 August 2019
DSM Summer School, Beijing 2019Uncategorised

First Dynamic Single-Molecule Summer School in China!

Yet another premiere! LUMICKS organized the very first Dynamic Single-Molecule Summer School at Tsinghua University in Beijing. During the three-day event, nineteen participants received in-depth training in both the theory and practice of dynamic single-molecule (DSM) techniques. Our application scientists dedicated the mornings for lectures on various topics involved in DSM…
Doenja Jansen
14 August 2019

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