Nelli Bossert, Author at LUMICKS

Blog posts

m-Trap® allows precise control of biological activities in synthetic membraneless organelles (MLOs) in real time

Until recently, the understanding of membraneless organelles (MLOs) was hindered by the inability to control their bioactivities in a precise manner. In a recent Nature Communications article from the lab of Huang and Sun, University of Hong Kong, researchers were able to overcome this obstacle by producing synthetic MLOs that…

Nelli Bossert23 August 2022

Blog posts

C-Trap^® experiments contribute to elucidating the role of the helicase HELQ in different mechanisms of DNA repair

A recent paper published in Nature by the group of Dr. Simon Boulton from the Francis Crick Institute enlightens the role played by the helicase HELQ in the context of DNA repair. The researchers took advantage of the combination of microfluidics, optical tweezers, and fluorescence microscopy of the C-Trap® to…

Nelli Bossert23 December 2021

Blog posts

ZAP-S binding prevents the refolding of SARS-CoV-2 RNA, inhibits programmed ribosomal frameshifting

A new Nature Communications article sheds light into the mechanisms that govern programmed ribosomal frameshifting (PRF) in SARS-CoV-2 virus, as demonstrated by C-Trap experiments.

Nelli Bossert13 December 2021

Blog posts

ParB sliding to non-specific DNA regions visualized using C-Trap^®

A recent work published in eLife by Francisco de Asis Balaguer et al. shed light on the interaction of ParB with DNA, the consequent DNA condensation, and the role of cytidine triphosphate (CTP) in this process – at a single-molecule level. Using the C-Trap® the researchers investigated the role of…

Nelli Bossert30 November 2021

Blog posts

Using C-Trap^® to unravel different binding modes of architectural DNA-binding proteins at different ionic conditions and DNA conformation

A recent study by Szu‐Ning Lin et al. for the first time provided direct information on the dynamics of the interaction between HU and DNA and how this interaction is influenced by ionic conditions and DNA conformation.

Nelli Bossert9 November 2021

Blog posts

Insights into the mechanism of Cas12a dynamics using C-Trap^®

A recent publication by Losito et al. from the lab of Prof. David Rueda (Imperial College London), reveals new information on the kinetics and mechanism of Cas12a-DNA interaction.

Nelli Bossert13 October 2021

Blog posts

C-Trap^® uncovers autonomous force generation of anillin contracting actin filaments

A recent publication by Kucera et al. in Nature Communications combined TIRF assays and Optical Tweezers measurements to investigate myosin-independent actin contraction that is relevant during cytokinesis and cell division. The authors found a new mechanism showing how anillin, a non-motor actin crosslinking and scaffolding protein, substitutes for the activity…

Nelli Bossert23 August 2021

Blog posts

Missense mutation in kinesin motor leads to faster detachment from microtubules measured by C-Trap^®

In a recent article published in Science Advances, researchers investigated the mechanical consequences of a missense mutation within a highly conserved region, P305L, in the kinesin motor family member A1 (KIF1A). By employing a single-molecule approach using the C-Trap® as well as biochemical and genetic assays, Lam et al. found…

Nelli Bossert15 July 2021

Blog posts

ssRNA significantly decreases RNA G-quadruplex stability measured by C-Trap^®

A recent article published in the Journal of Physical Chemistry Letters provides insight into the stability and folding dynamics of RNA G-quadruplexes (RG4). Using the C-Trap® optical tweezers, Ye et al. investigated the influence of a proximal single-stranded (ss) RNA sequence and found that its existence significantly impairs RG4 stability.…

Nelli Bossert24 June 2021

Blog posts

C-Trap^® reveals how HP1α-mediated heterochromatin modulates its stability in response to applied forces

In a recent publication by Keenen et al. in eLife, the authors uncover the biophysical properties of heterochromatin protein 1α (HP1α) and present a new model on how it mediates DNA condensation and phase separation. Employing a combination of ensemble and single-molecule assays, they found that within phase-separated HP1α-DNA condensates,…

Nelli Bossert9 June 2021

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Nelli Bossert

m-Trap® allows precise control of biological activities in synthetic membraneless organelles (MLOs) in real time

C-Trap^® experiments contribute to elucidating the role of the helicase HELQ in different mechanisms of DNA repair

ZAP-S binding prevents the refolding of SARS-CoV-2 RNA, inhibits programmed ribosomal frameshifting

ParB sliding to non-specific DNA regions visualized using C-Trap^®

Using C-Trap^® to unravel different binding modes of architectural DNA-binding proteins at different ionic conditions and DNA conformation

Insights into the mechanism of Cas12a dynamics using C-Trap^®

C-Trap^® uncovers autonomous force generation of anillin contracting actin filaments

Missense mutation in kinesin motor leads to faster detachment from microtubules measured by C-Trap^®

ssRNA significantly decreases RNA G-quadruplex stability measured by C-Trap^®

C-Trap^® reveals how HP1α-mediated heterochromatin modulates its stability in response to applied forces

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