Study Drug-Molecule Interactions at the Nanoscale

Part of: Drug Research

Visualization and characterization of small molecule-protein interactions.

In this example, optical tweezers are used to catch a DNA molecule tethered between two beads, while a motor protein and differently labeled small molecules are visualized by correlative fluorescence microscopy. The illustration shows how small molecules interact with the motor protein, thereby reducing or altering its activity. Alternatively, the small molecules can interact with the DNA template, resulting in barriers that restrict the movement of the proteins.

This is only one example of what can be investigated using this technology. Contact us to see how optical tweezers can benefit your research.

Solutions

C-Trap® Optical Tweezers Fluorescence & Label-free Microscopy
C-Trap

Optical Tweezers and Fluorescence Microscopy

The C-Trap is the world’s first instrument that allows simultaneous manipulation and visualization of molecular interactions in real-time. It combines high-resolution optical tweezers, confocal microscopy or STED nanoscopy with an advanced microfluidics system in a truly integrated and correlated solution.

M-Trap® Optical Tweezers Fluorescence & Label-free Microscopy
m-Trap

Optical Tweezers

The m-Trap is the first entry-level optical tweezers instrument specifically developed for high-resolution single-molecule research. Ultra-high force resolution and stability, with incredible throughput, ease of use and modularity ‒ all at an unprecedented price level.

Key Product FeaturesC-Trap®m-Trap®
Conformational changes and states
Force-induced structural transitions
Visualization of ligand interactions using fluorescence
Investigation of higher order structures using FRET
Rapid buffer exchange for fast experimental workflow

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