Multicolor detection of DNA overstretching

Multicolor Detection Application Note Now Online

Single-molecule force spectroscopy (SMFS) tools are widely used to study structural transitions of DNA during overstretching. However, as many of these tools only provide global information, the exact mechanisms that occur during these transitions remain unclear. Combining SMFS with visualization … Continue Reading

optical tweezers dna repair force extension manipulation visualization RAD51 Recombination

Investigation of the Role of RAD52-DNA Complex in DNA Repair Using Optical Tweezers CTFM and Microfluidics

The article “Human RAD52 Captures and Holds DNA Strands, Increases DNA flexibility, and Prevents Melting of Duplex DNA: Implications for DNA Recombination” was recently published in Cell Reports. Congratulations to Dr. Ineke Brouwer and all co-authors! In this paper optical tweezers … Continue Reading

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Study Published on DNA Compaction by Meiotic Protein SYCP3 using LUMICKS Technology

The article “Single-Molecule Observation of DNA Compaction by Meiotic Protein SYCP3” has recently been published in eLife Journal using optical tweezers-fluorescence microscopy. Congratulations to all the authors! In the paper by Syrjänen et al., optical tweezers-fluorescence microscopy was used to … Continue Reading

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LUMICKS’ AFS™ Installed at NUS

LUMICKS is happy to announce that an AFS™ system was installed at the National University of Singapore (NUS) in the lab of Professor Yan Jie. Professor Yan Jie and his group will use AFS™ along with their magnetic tweezers to … Continue Reading

DNA Repair Visualization Application Note Now Online

DNA repair, the collection of highly-regulated mechanisms by which a cell identifies and repairs DNA damage, remains one of the most essential processes of human life. Without DNA repair mechanisms cells lose the ability to transcribe important regions of their … Continue Reading

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Exonucleolysis and Replication by T7 DNA Polymerase Studied using Optical Tweezers and AFS™

The paper “Switching between Exonucleolysis and Replication by T7 DNA Polymerase Ensures High Fidelity” has recently been published in the Biophysical Journal using LUMICKS’ AFS™ technology and optical tweezers. We would like to congratulate all the authors! In the paper … Continue Reading