Single-molecule force spectroscopy (SMFS) tools are widely used to study structural transitions of DNA during overstretching. However, as many of these tools only provide global information, the exact mechanisms that occur during these transitions remain unclear. Combining SMFS with visualization … Continue Reading
Investigation of the Role of RAD52-DNA Complex in DNA Repair Using Optical Tweezers CTFM and Microfluidics
The article “Human RAD52 Captures and Holds DNA Strands, Increases DNA flexibility, and Prevents Melting of Duplex DNA: Implications for DNA Recombination” was recently published in Cell Reports. Congratulations to Dr. Ineke Brouwer and all co-authors! In this paper optical tweezers … Continue Reading
Study Published on DNA Compaction by Meiotic Protein SYCP3 using LUMICKS Technology
The article “Single-Molecule Observation of DNA Compaction by Meiotic Protein SYCP3” has recently been published in eLife Journal using optical tweezers-fluorescence microscopy. Congratulations to all the authors! In the paper by Syrjänen et al., optical tweezers-fluorescence microscopy was used to … Continue Reading
LUMICKS’ AFS™ Installed at NUS
LUMICKS is happy to announce that an AFS™ system was installed at the National University of Singapore (NUS) in the lab of Professor Yan Jie. Professor Yan Jie and his group will use AFS™ along with their magnetic tweezers to … Continue Reading
DNA Repair Visualization Application Note Now Online
DNA repair, the collection of highly-regulated mechanisms by which a cell identifies and repairs DNA damage, remains one of the most essential processes of human life. Without DNA repair mechanisms cells lose the ability to transcribe important regions of their … Continue Reading
Exonucleolysis and Replication by T7 DNA Polymerase Studied using Optical Tweezers and AFS™
The paper “Switching between Exonucleolysis and Replication by T7 DNA Polymerase Ensures High Fidelity” has recently been published in the Biophysical Journal using LUMICKS’ AFS™ technology and optical tweezers. We would like to congratulate all the authors! In the paper … Continue Reading